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PHD finger protein 8

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Target not currently curated in GtoImmuPdb

Target id: 2698

Nomenclature: PHD finger protein 8

Family: 1.14.11.- Histone demethylases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1060 Xp11.22 PHF8 PHD finger protein 8
Mouse - 1023 X F3 Phf8 PHD finger protein 8
Rat - 1023 Xq21 Phf8 PHD finger protein 8
Previous and Unofficial Names Click here for help
KDM7B | JHDM1F
Database Links Click here for help
Alphafold
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal Structure of human PHF8 in complex with Daminozide
PDB Id:  4DO0
Ligand:  daminozide
Resolution:  2.55Å
Species:  Human
References: 
Enzyme Reaction Click here for help
EC Number: 1.14.11.27

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
daminozide Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 6.3 pIC50 1
pIC50 6.3 (IC50 5.5x10-7 M) [1]
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Mental retardation syndrome, X-linked, Siderius type
Synonyms: X-linked intellectual disability, Siderius type [Orphanet: ORPHA85287]
OMIM: 300263
Orphanet: ORPHA85287

References

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1. Rose NR, Woon EC, Tumber A, Walport LJ, Chowdhury R, Li XS, King ON, Lejeune C, Ng SS, Krojer T et al.. (2012) Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem, 55 (14): 6639-43. [PMID:22724510]

How to cite this page

1.14.11.- Histone demethylases: PHD finger protein 8. Last modified on 13/08/2015. Accessed on 06/12/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2698.