PHD finger protein 8 | 1.14.11.- Histone demethylases | IUPHAR/BPS Guide to PHARMACOLOGY

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PHD finger protein 8

Target not currently curated in GtoImmuPdb

Target id: 2698

Nomenclature: PHD finger protein 8

Family: 1.14.11.- Histone demethylases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1060 Xp11.22 PHF8 PHD finger protein 8
Mouse - 795 X F3 Phf8 PHD finger protein 8
Rat - 1023 Xq21 Phf8 PHD finger protein 8
Previous and Unofficial Names
JHDM1F | KDM7B
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal Structure of human PHF8 in complex with Daminozide
PDB Id:  4DO0
Ligand:  daminozide
Resolution:  2.55Å
Species:  Human
References: 
Enzyme Reaction
EC Number: 1.14.11.27

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
daminozide Hs Inhibition 6.3 pIC50 1
pIC50 6.3 (IC50 5.5x10-7 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Mental retardation syndrome, X-linked, Siderius type
Synonyms: X-linked intellectual disability, Siderius type [Orphanet: ORPHA85287]
OMIM: 300263
Orphanet: ORPHA85287

References

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1. Rose NR, Woon EC, Tumber A, Walport LJ, Chowdhury R, Li XS, King ON, Lejeune C, Ng SS, Krojer T et al.. (2012) Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J. Med. Chem., 55 (14): 6639-43. [PMID:22724510]

How to cite this page

1.14.11.- Histone demethylases: PHD finger protein 8. Last modified on 13/08/2015. Accessed on 11/12/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2698.