ATPase family AAA domain containing 2B | 3.6.1.3 ATPases | IUPHAR/BPS Guide to PHARMACOLOGY

Top ▲

ATPase family AAA domain containing 2B

Target not currently curated in GtoImmuPdb

Target id: 2720

Nomenclature: ATPase family AAA domain containing 2B

Family: 3.6.1.3 ATPases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1453 2p24.1-p23.3 ATAD2B ATPase family AAA domain containing 2B
Mouse - 1460 12 A1.1 Atad2b ATPase family, AAA domain containing 2B
Rat - 418 6q14 Atad2b ATPase family, AAA domain containing 2B
Previous and Unofficial Names
ATPase family, AAA domain containing 2B | ATPase family
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.6.1.3

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
GSK8814 Hs Inhibition 7.7 pIC50 2
pIC50 7.7 (IC50 1.99x10-8 M) [2]
Description: By TR-FRET assay.
compound 23 [PMID: 31398032] Hs Inhibition 6.3 pIC50 1
pIC50 6.3 (IC50 5.01x10-7 M) [1]
Description: Measuring small-molecule competition using TR-FRET assay with ATAD2 construct 6 (Flag-6H-tev-ATAd2(981-1121) and the biotinylated triacetylated histone H4 peptide (SGRG-K(Ac)-GG-K(Ac)-GLG-K(Ac)-GGAKRHRKV-biotin).
General Comments
This is a bromo-domain containing protein involved in chromatin modification.

References

Show »

1. Bamborough P, Chung CW, Demont EH, Bridges AM, Craggs PD, Dixon DP, Francis P, Furze RC, Grandi P, Jones EJ et al.. (2019) A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit Qualification. J. Med. Chem., 62 (16): 7506-7525. [PMID:31398032]

2. Bamborough P, Chung CW, Demont EH, Furze RC, Bannister AJ, Che KH, Diallo H, Douault C, Grandi P, Kouzarides T et al.. (2016) A Chemical Probe for the ATAD2 Bromodomain. Angew. Chem. Int. Ed. Engl., 55 (38): 11382-6. [PMID:27530368]

How to cite this page

3.6.1.3 ATPases: ATPase family AAA domain containing 2B. Last modified on 12/08/2019. Accessed on 16/12/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2720.