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carbonic anhydrase 13

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Target not currently curated in GtoImmuPdb

Target id: 2748

Nomenclature: carbonic anhydrase 13

Abbreviated Name: CA XIII

Family: Carbonic anhydrases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 262 8q21.2 CA13 carbonic anhydrase 13
Mouse - 262 3 A1 Car13 carbonic anhydrase 13
Rat - 262 2q23 Car13 carbonic anhydrase 13
Previous and Unofficial Names Click here for help
carbonic anhydrase XIII
Database Links Click here for help
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 4.2.1.1

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
acetazolamide Small molecule or natural product Approved drug Ligand has a PDB structure Mm Inhibition 7.8 pKi 1
pKi 7.8 (Ki 1.7x10-8 M) [1]

References

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1. Avvaru BS, Wagner JM, Maresca A, Scozzafava A, Robbins AH, Supuran CT, McKenna R. (2010) Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors. Bioorg. Med. Chem. Lett., 20 (15): 4376-81. [PMID:20605094]

How to cite this page

Carbonic anhydrases: carbonic anhydrase 13. Last modified on 29/11/2018. Accessed on 27/11/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2748.