tubulin beta 3 class III | Tubulins | IUPHAR/BPS Guide to PHARMACOLOGY

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tubulin beta 3 class III

Target not currently curated in GtoImmuPdb

Target id: 2752

Nomenclature: tubulin beta 3 class III

Family: Tubulins

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 450 16q24.3 TUBB3 tubulin beta 3 class III
Mouse - 450 8 E1 Tubb3 tubulin
Rat - 450 19q12 Tubb3 tubulin
Previous and Unofficial Names
FEOM3 | tubulin, beta 3 class III | tubulin
Database Links
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
combretastatin A4 Hs Inhibition 8.2 pIC50 1
pIC50 8.2 (IC50 5.7x10-9 M) [1]
Description: Measuring cytotoxicity in cells expressing TUBB3 using the sulforhodamine B colorimetric assay.
Inhibitor Comments
Please see the Inhibitors table on the More detailed page for TUBB, for information on approved drugs which may act via this protein.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Cortical dysplasia, complex, with other brain malformations 1; CDCBM1
Synonyms: Cortical dysgenesis with pontocerebellar hypoplasia due to TUBB3 mutation
OMIM: 614039
Orphanet: ORPHA300570
Disease:  Fibrosis of extraocular muscles, congenital, 3A, with or without extraocular involvement; CFEOM3A
Synonyms: Congenital fibrosis of extraocular muscles [Orphanet: ORPHA45358]
OMIM: 600638
Orphanet: ORPHA45358

References

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1. Gangjee A, Zhao Y, Raghavan S, Rohena CC, Mooberry SL, Hamel E. (2013) Structure-activity relationship and in vitro and in vivo evaluation of the potent cytotoxic anti-microtubule agent N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride and its analogues as antitumor agents. J. Med. Chem., 56 (17): 6829-44. [PMID:23895532]

How to cite this page

Tubulins: tubulin beta 3 class III. Last modified on 29/01/2016. Accessed on 28/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2752.