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BCR activator of RhoGEF and GTPase

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Target not currently curated in GtoImmuPdb

Target id: 2755

Nomenclature: BCR activator of RhoGEF and GTPase

Family: BCR family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1271 22q11.23 BCR BCR activator of RhoGEF and GTPase
Mouse - 1270 10 38.49 cM Bcr BCR activator of RhoGEF and GTPase
Rat - - 20p12 Bcr BCR activator of RhoGEF and GTPase
Previous and Unofficial Names Click here for help
BCR | BCR1 | Bcr1 | BCR, RhoGEF and GTPase activating protein | breakpoint cluster region | renal carcinoma antigen NY-REN-26
Database Links Click here for help
Alphafold
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 2.7.11.1
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 4 GO processes, IEA only
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GO:0002692 negative regulation of cellular extravasation IEA
GO:0043314 negative regulation of neutrophil degranulation IEA
GO:0050728 negative regulation of inflammatory response IEA
GO:0050766 positive regulation of phagocytosis IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0002692 negative regulation of cellular extravasation IEA
GO:0043314 negative regulation of neutrophil degranulation IEA
GO:0050728 negative regulation of inflammatory response IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0060216 definitive hemopoiesis IEA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0002692 negative regulation of cellular extravasation IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0043314 negative regulation of neutrophil degranulation IEA
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Chronic myeloid leukemia
Disease Ontology: DOID:8552
OMIM: 608232
Orphanet: ORPHA521
Disease:  Precursor B-cell acute lymphoblastic leukemia
Synonyms: Acute lymphocytic leukemia [Disease Ontology: DOID:9952]
Leukemia, acute lymphoblastic; ALL [OMIM: 613065]
Leukemia, B-cell acute lymphoblastic, susceptibility to [OMIM: 613065]
Disease Ontology: DOID:9952
OMIM: 613065
Orphanet: ORPHA99860
Disease:  Precursor T-cell acute lymphoblastic leukemia
Synonyms: Acute lymphocytic leukemia [Disease Ontology: DOID:9952]
Leukemia, acute lymphoblastic; ALL [OMIM: 613065]
Leukemia, T-cell acute lymphoblastic, susceptibility to [OMIM: 613065]
Disease Ontology: DOID:9952
OMIM: 613065
Orphanet: ORPHA99861

How to cite this page

BCR family: BCR activator of RhoGEF and GTPase. Last modified on 27/03/2019. Accessed on 27/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2755.