Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	573	14q32.33	ASPG	asparaginase
Mouse	-	564	12 F1	Aspg	asparaginase
Rat	-	564	6q32	Aspg	asparaginase

Previous and Unofficial Names

60 kDa lysophospholipase | GPA/WT | LPP60 | asparaginase homolog (S. cerevisiae)

Database Links
Alphafold	Q86U10 (Hs), A0JNU3 (Mm), O88202 (Rn)
BRENDA	3.1.1.5, 3.1.1.47, 3.5.1.1
CATH/Gene3D	3.40.50.1170, 3.40.50.40, 1.25.40.20
Ensembl Gene	ENSG00000166183 (Hs), ENSMUSG00000037686 (Mm), ENSRNOG00000012843 (Rn)
Entrez Gene	374569 (Hs), 104816 (Mm), 246266 (Rn)
Human Protein Atlas	ENSG00000166183 (Hs)
KEGG Enzyme	3.1.1.5, 3.1.1.47, 3.5.1.1
KEGG Gene	hsa:374569 (Hs), mmu:104816 (Mm), rno:246266 (Rn)
Pharos	Q86U10 (Hs)
RefSeq Nucleotide	NM_001080464 (Hs), NM_001081169 (Mm), NM_144750 (Rn)
RefSeq Protein	NP_001073933 (Hs), NP_001074638 (Mm), NP_653351 (Rn)
UniProtKB	Q86U10 (Hs), A0JNU3 (Mm), O88202 (Rn)
Wikipedia	ASPG (Hs)

Enzyme Reaction
EC Number: 3.1.1.5 EC Number: 3.1.1.47 EC Number: 3.5.1.1

General Comments

This protein has multiple functions. It acts as a lysophospholipase, a transacylase, a platelet-activating factor (PAF) acetylhydrolase and an L-asparaginase. L-asparaginase catalyses the deamination of asparagine to aspartic acid and a single ammonium ion. This action decreases circulating free asparagine in plasma. Synthetic versions of L-asparaginase (e.g. crisantaspase) are used for clinical antineoplastic activity in acute lymphoblastic leukemia (ALL). ALL cells lack endogenous asparagine synthase and so are unable to generate the asparagine that is required to supply the protein synthesis pathway and feed tumour cell proliferation. Advanced combination therapeutic regimens have been developed which can utilise longer acting enzyme formulations such as pegaspargase and calaspargase pegol (Asparlas®) which are pegylated to extend circulating half-life [1-3].