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galactosamine (N-acetyl)-6-sulfatase

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Target not currently curated in GtoImmuPdb

Target id: 2765

Nomenclature: galactosamine (N-acetyl)-6-sulfatase

Family: 3.1.-.- Ester bond enzymes

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 522 16q24.3 GALNS galactosamine (N-acetyl)-6-sulfatase
Mouse - 520 8 E1 Galns galactosamine (N-acetyl)-6-sulfatase
Rat - 524 19q12 Galns galactosamine (N-acetyl)-6-sulfatase
Previous and Unofficial Names Click here for help
N-acetylgalactosamine-6-sulfatase | galactosamine (N-acetyl)-6-sulfate sulfatase
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Cellular signalling
Physiological Functions Click here for help
GALNS catalyses the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate.
Species:  Human
Tissue:  placenta
References:  2
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Mucopolysaccharidosis type IVA
Disease Ontology: DOID:12804
OMIM: 253000
Orphanet: ORPHA582
Therapeutic use:  Elosufase alfa is a recombinant enzyme replacement therapy.
References:  1,3


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1. Glössl J, Kresse H. (1982) Impaired degradation of keratan sulphate by Morquio A fibroblasts. Biochem J, 203 (1): 335-8. [PMID:6213226]

2. Lim CT, Horwitz AL. (1981) Purification and properties of human N-acetylgalactosamine-6-sulfate sulfatase. Biochim Biophys Acta, 657 (2): 344-55. [PMID:7213753]

3. Yutaka T, Okada S, Kato T, Inui K, Yabuuhi H. (1982) Galactose 6-sulfate sulfatase activity in Morquio syndrome. Clin Chim Acta, 122 (2): 169-80. [PMID:6809361]

How to cite this page

3.1.-.- Ester bond enzymes: galactosamine (N-acetyl)-6-sulfatase. Last modified on 13/08/2015. Accessed on 21/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,