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bromodomain adjacent to zinc finger domain 1B

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Target not currently curated in GtoImmuPdb

Target id: 2774

Nomenclature: bromodomain adjacent to zinc finger domain 1B

Family: Non-enzymatic BRD containing proteins

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1483 7q11.23 BAZ1B bromodomain adjacent to zinc finger domain 1B
Mouse - 1479 5 G2 Baz1b bromodomain adjacent to zinc finger domain, 1B
Rat - 1476 12q12 Baz1b bromodomain adjacent to zinc finger domain, 1B
Previous and Unofficial Names Click here for help
WBSCR10 | WBSCR9 | Williams-Beuren syndrome chromosome region 10 | WSTF | bromodomain adjacent to zinc finger domain, 1B | bromodomain adjacent to zinc finger domain
Database Links Click here for help
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Physiological Consequences of Altering Gene Expression Click here for help
BAZ1B (WSTF)-deficient mice exhibit some of the heart defects and abnormal calcium metabolism observed in Williams syndrome
Species:  Mouse
Tissue:  In vivo, cardiac tissue
Technique:  Gene knockout
References:  1
Gene Expression and Pathophysiology Click here for help
Deletion of BAZ1B has been identified in patients with Williams-Beuren syndrome (WBS)
Tissue or cell type: 
Pathophysiology:  Williams-Beuren syndrome (WBS)
Species:  Human
Technique:  Fluorescence in situ hybridization and gene doasge analysis
References:  2-3

References

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1. Kitagawa H, Fujiki R, Yoshimura K, Oya H, Kato S. (2011) Williams syndrome is an epigenome-regulator disease. Endocr. J., 58 (2): 77-85. [PMID:21242649]

2. Lu X, Meng X, Morris CA, Keating MT. (1998) A novel human gene, WSTF, is deleted in Williams syndrome. Genomics, 54 (2): 241-9. [PMID:9828126]

3. Peoples RJ, Cisco MJ, Kaplan P, Francke U. (1998) Identification of the WBSCR9 gene, encoding a novel transcriptional regulator, in the Williams-Beuren syndrome deletion at 7q11.23. Cytogenet. Cell Genet., 82 (3-4): 238-46. [PMID:9858827]

How to cite this page

Non-enzymatic BRD containing proteins: bromodomain adjacent to zinc finger domain 1B. Last modified on 13/02/2017. Accessed on 04/12/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2774.