regulator of G-protein signaling 21

Target not currently curated in GtoImmuPdb

Target id: 2809

Nomenclature: regulator of G-protein signaling 21

Abbreviated Name: RGS21

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	152	1q31.2	RGS21	regulator of G protein signaling 21	1,3,7
Mouse	-	152	1 F	Rgs21	regulator of G-protein signalling 21	1-2
Rat	-	-	13	LOC102551739	regulator of G-protein signaling 21-like	6

Database Links
Alphafold	Q2M5E4 (Hs)
CATH/Gene3D	1.10.196.10
Ensembl Gene	ENSG00000253148 (Hs), ENSMUSG00000098509 (Mm)
Entrez Gene	431704 (Hs), 624910 (Mm), 102551739 (Rn)
Human Protein Atlas	ENSG00000253148 (Hs)
KEGG Gene	hsa:431704 (Hs), mmu:624910 (Mm), rno:102551739 (Rn)
OMIM	612407 (Hs)
Pharos	Q2M5E4 (Hs)
RefSeq Nucleotide	NM_001039152 (Hs), NM_001290269 (Mm)
RefSeq Protein	NP_001034241 (Hs), NP_001277198 (Mm)
UniProtKB	Q2M5E4 (Hs)
Wikipedia	RGS21 (Hs)

Associated Proteins

G Proteins
Name	References
Gαi0, Gαq/11	1-2

Interacting Proteins
Name	Effect	References
Transducin	Accelerates the GTPase activity of the subunit	1
Gusducin	Accelerates the GTPase activity of the subunit	2,6

Tissue Distribution

Heart, brain, placenta, lung, sinonasal mucosa, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocyte.

Species:	Human
Technique:	RT-PCR
References:	2-3

Subset of taste sensory cells

Species:	Mouse
Technique:	RT-PCR, in situ hybridization
References:	1

Lung epithelial cells

Species:	Mouse
Technique:	RT-PCR, in situ hybridization
References:	1

Subset of taste sensory cells

Species:	Rat
Technique:	RT-PCR, in situ hybridization
References:	6

Functional Assays

Accelerated GTP hydrolysis from Gα subunit.

Species:	Human
Tissue:	Airway epithelium
Response measured:	Inactivation of G-protein
References:	1-2

Physiological Functions

Negative regulation of bitter tastant mediated transduction.

Species:	Human
Tissue:	Airway epithelium
References:	1-2

Physiological Consequences of Altering Gene Expression

Overexpression of the wild type RGS21 inhibited bitter tastant (denatonium) induced reduction in cAMP.

Species:	Human
Tissue:	16-HEB cells
Technique:	Gene overexpression
References:	1

Reduced chorda tympani nerve recordings in Rgs21-null mice.

Species:	Mouse
Tissue:	chorda tympani nerves
Technique:
References:	4

Rgs21-null mice have blunted aversion to quinine and denatonium, and blunted preference for monosodium glutamate, the sweeteners sucrose and SC45647, and NaCl.

Species:	Mouse
Tissue:	Tongue
Technique:	Two-bottle preference test
References:	4

Biologically Significant Variants

Type:	Single nucleotide polymorphism
Species:	Human
Description:	RGS21 associated with celiac disease. The complete study showed 54 single-nucleotide polymorphisms (SNPs) in 5 genes associated with celiac disease (TAGAP, IL18R1, RGS21, PLEK, and CCR9).
References:	5

References

Show »« Hide

1. Cohen SP, Buckley BK, Kosloff M, Garland AL, Bosch DE, Cheng Jr G, Radhakrishna H, Brown MD, Willard FS, Arshavsky VY et al.. (2012) Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia. J Biol Chem, 287 (50): 41706-19. [PMID:23095746]

2. Kimple AJ, Garland AL, Cohen SP, Setola V, Willard FS, Zielinski T, Lowery RG, Tarran R, Siderovski DP. (2014) RGS21, a regulator of taste and mucociliary clearance?. Laryngoscope, 124 (3): E56-63. [PMID:23908053]

3. Li X, Chen L, Ji C, Liu B, Gu J, Xu J, Zou X, Gu S, Mao Y. (2005) Isolation and expression pattern of RGS21 gene, a novel RGS member. Acta Biochim Pol, 52 (4): 943-6. [PMID:16302027]

4. Schroer AB, Gross JD, Kaski SW, Wix K, Siderovski DP, Vandenbeuch A, Setola V. (2018) Development of Full Sweet, Umami, and Bitter Taste Responsiveness Requires Regulator of G protein Signaling-21 (RGS21). Chem Senses, 43 (5): 367-378. [PMID:29701767]

5. Sharma A, Liu X, Hadley D, Hagopian W, Liu E, Chen WM, Onengut-Gumuscu S, Simell V, Rewers M, Ziegler AG et al.. (2016) Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort. PLoS One, 11 (3): e0152476. [PMID:27015091]

6. von Buchholtz L, Elischer A, Tareilus E, Gouka R, Kaiser C, Breer H, Conzelmann S. (2004) RGS21 is a novel regulator of G protein signalling selectively expressed in subpopulations of taste bud cells. Eur J Neurosci, 19 (6): 1535-44. [PMID:15066150]

7. Zhang D, Pang Z, Li S, Jiang W, Wang S, Thomassen M, Hjelmborg JV, Kruse TA, Ohm Kyvik K, Christensen K et al.. (2012) Genome-wide linkage and association scans for pulse pressure in Chinese twins. Hypertens Res, 35 (11): 1051-7. [PMID:22763476]

Contributors

Show »« Hide

How to cite this page

Select citation format:

regulator of G-protein signaling 21

Contents:

References

Contributors

Contributors:

How to cite this page