regulator of G-protein signaling 21 | R4 family | IUPHAR/BPS Guide to PHARMACOLOGY

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regulator of G-protein signaling 21

Target not currently curated in GtoImmuPdb

Target id: 2809

Nomenclature: regulator of G-protein signaling 21

Abbreviated Name: RGS21

Family: R4 family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 152 1q31.2 RGS21 regulator of G protein signaling 21 1,3,5
Mouse - 152 1 F Rgs21 regulator of G-protein signalling 21 1-2
Rat - - 13 LOC102551739 regulator of G-protein signaling 21-like 4
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Associated Proteins
G Proteins
Name References
Gαi0, Gαq/11 1-2
Interacting Proteins
Name Effect References
Transducin Accelerates the GTPase activity of the subunit 1
Gusducin Accelerates the GTPase activity of the subunit 2,4
Tissue Distribution
Heart, brain, placenta, lung, sinonasal mucosa, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocyte.
Species:  Human
Technique:  RT-PCR
References:  2-3
Subset of taste sensory cells
Species:  Mouse
Technique:  RT-PCR, in situ hybridization
References:  1
Lung epithelial cells
Species:  Mouse
Technique:  RT-PCR, in situ hybridization
References:  1
Subset of taste sensory cells
Species:  Rat
Technique:  RT-PCR, in situ hybridization
References:  4
Functional Assays
Accelerated GTP hydrolysis from Gα subunit.
Species:  Human
Tissue:  Airway epithelium
Response measured:  Inactivation of G-protein
References:  1-2
Physiological Functions
Negative regulation of bitter tastant mediated transduction.
Species:  Human
Tissue:  Airway epithelium
References:  1-2
Physiological Consequences of Altering Gene Expression
Overexpression of the wild type RGS21 inhibited bitter tastant (denatonium) induced reduction in cAMP.
Species:  Human
Tissue:  16-HEB cells
Technique:  Gene overexpression
References:  1

References

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1. Cohen SP, Buckley BK, Kosloff M, Garland AL, Bosch DE, Cheng Jr G, Radhakrishna H, Brown MD, Willard FS, Arshavsky VY et al.. (2012) Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia. J. Biol. Chem., 287 (50): 41706-19. [PMID:23095746]

2. Kimple AJ, Garland AL, Cohen SP, Setola V, Willard FS, Zielinski T, Lowery RG, Tarran R, Siderovski DP. (2014) RGS21, a regulator of taste and mucociliary clearance?. Laryngoscope, 124 (3): E56-63. [PMID:23908053]

3. Li X, Chen L, Ji C, Liu B, Gu J, Xu J, Zou X, Gu S, Mao Y. (2005) Isolation and expression pattern of RGS21 gene, a novel RGS member. Acta Biochim. Pol., 52 (4): 943-6. [PMID:16302027]

4. von Buchholtz L, Elischer A, Tareilus E, Gouka R, Kaiser C, Breer H, Conzelmann S. (2004) RGS21 is a novel regulator of G protein signalling selectively expressed in subpopulations of taste bud cells. Eur. J. Neurosci., 19 (6): 1535-44. [PMID:15066150]

5. Zhang D, Pang Z, Li S, Jiang W, Wang S, Thomassen M, Hjelmborg JV, Kruse TA, Ohm Kyvik K, Christensen K et al.. (2012) Genome-wide linkage and association scans for pulse pressure in Chinese twins. Hypertens. Res., 35 (11): 1051-7. [PMID:22763476]

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