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regulator of G-protein signaling 11

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Target not currently curated in GtoImmuPdb

Target id: 2814

Nomenclature: regulator of G-protein signaling 11

Abbreviated Name: RGS11

Family: R7 family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 467 16p13.3 RGS11 regulator of G protein signaling 11
Mouse - 443 17 A3.3 Rgs11 regulator of G-protein signaling 11
Rat - 66 10q12 Rgs11 regulator of G-protein signaling 11
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Associated Proteins Click here for help
G Proteins
Name References
Gαi0 6,18
Interacting Proteins
Name Effect References
R7BP Membrane targeting, protein stabilization. 10,14,19
R9AP Membrane targeting, protein stabilization, enhances GAP activity. 2,7,11,15,19
Gbeta5 RGS11 protein stability 14,18
Associated Protein Comments
More active towards Gi than other R7 subtypes (see [6]).
Tissue Distribution Click here for help
Retina, brain, pancreas.
Species:  Human
Technique:  Northen blot.
References:  18
Brain- specifically high in cerebellum
Species:  Human
Technique:  RT-PCR
References:  9
Heart, lung, intestine and placenta.
Species:  Human
Technique:  RT-PCR
References:  9
Brain: subfornical organ and locus coeruleus.
Species:  Rat
Technique:  In situ hybridisation.
References:  5
Physiological Functions Click here for help
Accelerates the early light response of ON-bipolar cells.
Species:  Mouse
Tissue:  Retina (ON-bipolar cells).
References:  2-3,7,12,22
May play a role in follicular maturation.
Species:  Human
Tissue:  Cell culture.
References:  1,16
Transcripts for RGS4, RGS5, RGS6, RGS7, and RGS11 are upregulated during neuronal differentiation.
Species:  Human
Tissue:  Neural progenitor cells (hNPs).
References:  20
Knockdown of Rgs11 reduces [D-Ala(2)]deltorphin II analgesic effects.
Species:  Mouse
Tissue:  Brain
References:  4
Physiological Consequences of Altering Gene Expression Click here for help
Rgs7-knockout mice display normal light responses but double Rgs7/Rgs11 knockout mice show an absence of the b-wave as measured by electroretinograms.
Species:  Mouse
Tissue:  In vivo, retina.
Technique:  Gene knockout.
References:  3,17,22
Overexpression of RGS11 promotes cell migration and associates with advanced stages and aggressiveness of lung adenocarcinoma.
Species:  Human
Tissue:  Tumor cells.
Technique:  Gene overexpression.
References:  21
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Congenital stationary night blindness
Description: Congenital stationary night blindness (CSNB) refers to a group of nonprogressive retinal disorders characterized predominantly by abnormal function of the rod system. The condition may be X-linked (the most common form), autosomal recessive, or autosomal dominant. Types 1A and 2A are X-linked.
OMIM: 310500, 300071
References:  13
Disease:  Night blindness
Description: Night blindness (nyctalopia) is a condition making it difficult or impossible to see in relatively low light. It is a symptom of several eye diseases.
References:  8


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1. Barzilay E, Yung Y, Shapira L, Haas J, Ophir L, Yerushalmi GM, Maman E, Hourvitz A. (2014) Differential expression of poliovirus receptor, regulator of G-protein signaling 11 and erythrocyte protein band 4.1-like 3 in human granulosa cells during follicular growth and maturation. Gynecol Endocrinol, 30 (9): 660-3. [PMID:24828608]

2. Cao Y, Masuho I, Okawa H, Xie K, Asami J, Kammermeier PJ, Maddox DM, Furukawa T, Inoue T, Sampath AP et al.. (2009) Retina-specific GTPase accelerator RGS11/G beta 5S/R9AP is a constitutive heterotrimer selectively targeted to mGluR6 in ON-bipolar neurons. J Neurosci, 29 (29): 9301-13. [PMID:19625520]

3. Cao Y, Pahlberg J, Sarria I, Kamasawa N, Sampath AP, Martemyanov KA. (2012) Regulators of G protein signaling RGS7 and RGS11 determine the onset of the light response in ON bipolar neurons. Proc Natl Acad Sci USA, 109 (20): 7905-10. [PMID:22547806]

4. Garzón J, López-Fando A, Sánchez-Blázquez P. (2003) The R7 subfamily of RGS proteins assists tachyphylaxis and acute tolerance at mu-opioid receptors. Neuropsychopharmacology, 28 (11): 1983-90. [PMID:12902995]

5. Gold SJ, Ni YG, Dohlman HG, Nestler EJ. (1997) Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain. J Neurosci, 17 (20): 8024-37. [PMID:9315921]

6. Hooks SB, Waldo GL, Corbitt J, Bodor ET, Krumins AM, Harden TK. (2003) RGS6, RGS7, RGS9, and RGS11 stimulate GTPase activity of Gi family G-proteins with differential selectivity and maximal activity. J Biol Chem, 278 (12): 10087-93. [PMID:12531899]

7. Jeffrey BG, Morgans CW, Puthussery T, Wensel TG, Burke NS, Brown RL, Duvoisin RM. (2010) R9AP stabilizes RGS11-G beta5 and accelerates the early light response of ON-bipolar cells. Vis Neurosci, 27 (1-2): 9-17. [PMID:20100392]

8. Kondo M, Das G, Imai R, Santana E, Nakashita T, Imawaka M, Ueda K, Ohtsuka H, Sakai K, Aihara T et al.. (2015) A Naturally Occurring Canine Model of Autosomal Recessive Congenital Stationary Night Blindness. PLoS ONE, 10 (9): e0137072. [PMID:26368928]

9. Larminie C, Murdock P, Walhin JP, Duckworth M, Blumer KJ, Scheideler MA, Garnier M. (2004) Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system. Brain Res Mol Brain Res, 122 (1): 24-34. [PMID:14992813]

10. Martemyanov KA, Yoo PJ, Skiba NP, Arshavsky VY. (2005) R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family. J Biol Chem, 280 (7): 5133-6. [PMID:15632198]

11. Masuho I, Celver J, Kovoor A, Martemyanov KA. (2010) Membrane anchor R9AP potentiates GTPase-accelerating protein activity of RGS11 x Gbeta5 complex and accelerates inactivation of the mGluR6-G(o) signaling. J Biol Chem, 285 (7): 4781-7. [PMID:20007977]

12. Mojumder DK, Qian Y, Wensel TG. (2009) Two R7 regulator of G-protein signaling proteins shape retinal bipolar cell signaling. J Neurosci, 29 (24): 7753-65. [PMID:19535587]

13. Neuillé M, Morgans CW, Cao Y, Orhan E, Michiels C, Sahel JA, Audo I, Duvoisin RM, Martemyanov KA, Zeitz C. (2015) LRIT3 is essential to localize TRPM1 to the dendritic tips of depolarizing bipolar cells and may play a role in cone synapse formation. Eur J Neurosci, 42 (3): 1966-75. [PMID:25997951]

14. Saleem Y, Kim KS. (2009) RGS11 interacts preferentially with R7BP over Galpha(oa)--characterization of Gbeta5-free RGS11. Biochem Biophys Res Commun, 386 (1): 65-70. [PMID:19497306]

15. Sarria I, Orlandi C, McCall MA, Gregg RG, Martemyanov KA. (2016) Intermolecular Interaction between Anchoring Subunits Specify Subcellular Targeting and Function of RGS Proteins in Retina ON-Bipolar Neurons. J Neurosci, 36 (10): 2915-25. [PMID:26961947]

16. Segers I, Adriaenssens T, Smitz J. (2012) Expression patterns of poliovirus receptor, erythrocyte protein band 4.1-like 3, regulator of g-protein signaling 11, and oxytocin receptor in mouse ovarian cells during follicle growth and early luteinization in vitro and in vivo. Biol Reprod, 86 (1): 1-11. [PMID:21957189]

17. Shim H, Wang CT, Chen YL, Chau VQ, Fu KG, Yang J, McQuiston AR, Fisher RA, Chen CK. (2012) Defective retinal depolarizing bipolar cells in regulators of G protein signaling (RGS) 7 and 11 double null mice. J Biol Chem, 287 (18): 14873-9. [PMID:22371490]

18. Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP. (1998) A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits. Proc Natl Acad Sci USA, 95 (22): 13307-12. [PMID:9789084]

19. Song JH, Song H, Wensel TG, Sokolov M, Martemyanov KA. (2007) Localization and differential interaction of R7 RGS proteins with their membrane anchors R7BP and R9AP in neurons of vertebrate retina. Mol Cell Neurosci, 35 (2): 311-9. [PMID:17442586]

20. Tuggle K, Ali MW, Salazar H, Hooks SB. (2014) Regulator of G protein signaling transcript expression in human neural progenitor differentiation: R7 subfamily regulation by DNA methylation. Neurosignals, 22 (1): 43-51. [PMID:24903911]

21. Yang SH, Li CF, Chu PY, Ko HH, Chen LT, Chen WW, Han CH, Lung JH, Shih NY. (2016) Overexpression of regulator of G protein signaling 11 promotes cell migration and associates with advanced stages and aggressiveness of lung adenocarcinoma. Oncotarget, 7 (21): 31122-36. [PMID:27105500]

22. Zhang J, Jeffrey BG, Morgans CW, Burke NS, Haley TL, Duvoisin RM, Brown RL. (2010) RGS7 and -11 complexes accelerate the ON-bipolar cell light response. Invest Ophthalmol Vis Sci, 51 (2): 1121-9. [PMID:19797214]


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