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R7 family C

Formerly known as: C family of RGS proteins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The members of the R7 family of RGS proteins [1] are more complex structures than the R4 family and are closely related to the C. elegans homologues EGL-10 and EAT-16 that were identified in the early stage of RGS protein research [2,5]. Apart from the RGS domain, several additional domains are present in these proteins that mediate protein-protein interactions, sub-cellular localization and protein stability. All R7 family members form obligatory dimers with Gβ5 through the G-γ like (GGL) domain and the disheveled-EGL10-Pleckstrin homology (DEP) domain [6]. The DEP and DEP helical extension domain interact with R7 binding protein (R7BP) or RGS9 anchoring protein (R9AP; in retina) that serves as a plasma membrane anchoring mechanism [3-4].

Targets

RGS6 (regulator of G-protein signaling 6) C Show summary » More detailed page

RGS7 (regulator of G-protein signaling 7) C Show summary » More detailed page

RGS9 (regulator of G-protein signaling 9) C Show summary » More detailed page

RGS11 (regulator of G-protein signaling 11) C Show summary » More detailed page

References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.