Top ▲
Gene and Protein Information ![]() |
||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 334 | 9q34.2 | WDR5 | WD repeat domain 5 | |
Mouse | - | 334 | 2 A3 | Wdr5 | WD repeat domain 5 | |
Rat | - | 334 | 3p12 | Wdr5 | WD repeat domain 5 |
Previous and Unofficial Names ![]() |
CFAP89 | cilia and flagella associated protein 89 | SWD3, Set1c WD40 repeat protein |
Database Links ![]() |
|
ChEMBL Target | CHEMBL1075317 (Hs) |
Ensembl Gene | ENSG00000196363 (Hs), ENSMUSG00000026917 (Mm), ENSRNOG00000008212 (Rn) |
Entrez Gene | 11091 (Hs), 140858 (Mm), 362093 (Rn) |
Human Protein Atlas | ENSG00000196363 (Hs) |
KEGG Gene | hsa:11091 (Hs), mmu:140858 (Mm), rno:362093 (Rn) |
OMIM | 609012 (Hs) |
Pharos | P61964 (Hs) |
RefSeq Nucleotide | NM_017588 (Hs), NM_080848 (Mm), NM_001039034 (Rn) |
RefSeq Protein | NP_060058 (Hs), NP_543124 (Mm), NP_001034123 (Rn) |
SynPHARM | 81844 (in complex with OICR-9429) |
UniProtKB | P61964 (Hs), P61965 (Mm), Q498M4 (Rn) |
Wikipedia | WDR5 (Hs) |
Selected 3D Structures ![]() |
|||||||||||||
![]() |
|
Download all structure-activity data for this target as a CSV file
Antagonists | |||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||
|
Immuno Process Associations | |||||||||
|
|||||||||
|
General Comments |
WDR5 is involved in the formation of heterotrimeric or multiprotein complexes eg the histone acetyltransferase complex and the histone methyltransferase complex [3-4]. Members of the WD repeat-containing protein family are involved in many cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. WDR5 is reported to associate with the long non-coding RNA HOTTIP which drives histone H3 lysine 4 trimethylation and gene transcription [2]. |
1. SGC. OICR-9429 - a chemical probe for WDR5. Accessed on 03/03/2015. Modified on 03/03/2015. thesgc.org, http://www.thesgc.org/node/9204
2. Wang KC, Yang YW, Liu B, Sanyal A, Corces-Zimmerman R, Chen Y, Lajoie BR, Protacio A, Flynn RA, Gupta RA et al.. (2011) A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression. Nature, 472 (7341): 120-4. [PMID:21423168]
3. Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W. (2003) Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. Genes Dev., 17 (7): 896-911. [PMID:12670868]
4. Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML. (2004) Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Mol. Cell. Biol., 24 (13): 5639-49. [PMID:15199122]
WD repeat-containing proteins: WD repeat domain 5. Last modified on 08/09/2015. Accessed on 01/03/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2831.