notch receptor 3 | Notch receptors | IUPHAR/BPS Guide to PHARMACOLOGY

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notch receptor 3

Target not currently curated in GtoImmuPdb

Target id: 2860

Nomenclature: notch receptor 3

Family: Notch receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 2321 19p13.2-p13.1 NOTCH3 notch receptor 3
Mouse 1 2318 17 B1 Notch3 notch 3
Rat 1 2319 7q11 Notch3 notch 3
Previous and Unofficial Names
CADASIL | CASIL | IMF2 | notch 3 | Notch homolog 3 (Drosophila)
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein

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Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
tarextumab Hs Binding 9.9 pKd 1
pKd 9.9 (Kd 1.2x10-10 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy; CADASIL
Synonyms: Hereditary multi-infarct dementia [Orphanet: ORPHA136]
OMIM: 125310
Orphanet: ORPHA136
Disease:  Lateral meningocele syndrome; LMNS
OMIM: 130720
Orphanet: ORPHA2789
Disease:  Myofibromatosis, infantile, 2; IMF2
Synonyms: Infantile myofibromatosis [Orphanet: ORPHA2591]
OMIM: 615293
Orphanet: ORPHA2591


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1. Gurney AL, Hoey TC, van der Horst ETH, Sato AK, Liu YC, Bruhns MF, Lewicki JA. (2012) Antibodies to notch receptors. Patent number: US8226943 B2. Assignee: Oncomed Pharmaceuticals, Inc.. Priority date: 08/07/2008. Publication date: 24/07/2012.

How to cite this page

Notch receptors: notch receptor 3. Last modified on 27/03/2019. Accessed on 17/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY,