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notch receptor 3

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Target not currently curated in GtoImmuPdb

Target id: 2860

Nomenclature: notch receptor 3

Family: Notch receptors

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 2321 19p13.12 NOTCH3 notch receptor 3
Mouse 1 2318 17 17.37 cM Notch3 notch 3
Rat 1 2319 7q11 Notch3 notch receptor 3
Previous and Unofficial Names Click here for help
CADASIL | CASIL | IMF2 | notch 3 | Notch homolog 3 (Drosophila)
Database Links Click here for help
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file go icon to follow link

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
tarextumab Peptide Primary target of this compound Click here for species-specific activity table Hs Binding 9.9 pKd 1
pKd 9.9 (Kd 1.2x10-10 M) [1]
Immuno Process Associations
Immuno Process:  Tissue repair
GO Annotations:  Associated to 1 GO processes
GO:0042246 tissue regeneration IEP
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy; CADASIL
Synonyms: Hereditary multi-infarct dementia [Orphanet: ORPHA136]
OMIM: 125310
Orphanet: ORPHA136
Disease:  Lateral meningocele syndrome; LMNS
OMIM: 130720
Orphanet: ORPHA2789
Disease:  Myofibromatosis, infantile, 2; IMF2
Synonyms: Infantile myofibromatosis [Orphanet: ORPHA2591]
OMIM: 615293
Orphanet: ORPHA2591

References

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1. Gurney AL, Hoey TC, van der Horst ETH, Sato AK, Liu YC, Bruhns MF, Lewicki JA. (2012) Antibodies to notch receptors. Patent number: US8226943 B2. Assignee: Oncomed Pharmaceuticals, Inc.. Priority date: 08/07/2008. Publication date: 24/07/2012.

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