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notch receptor 3

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Target not currently curated in GtoImmuPdb

Target id: 2860

Nomenclature: notch receptor 3

Family: Notch receptors

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 2321 19p13.12 NOTCH3 notch receptor 3
Mouse 1 2318 17 17.37 cM Notch3 notch 3
Rat 1 2319 7q11 Notch3 notch receptor 3
Previous and Unofficial Names Click here for help
CADASIL | CASIL | IMF2 | notch 3 | Notch homolog 3 (Drosophila)
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein

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Antibody Sp. Action Value Parameter Reference
tarextumab Peptide Primary target of this compound Click here for species-specific activity table Hs Binding 9.9 pKd 1
pKd 9.9 (Kd 1.2x10-10 M) [1]
Immuno Process Associations
Immuno Process:  Tissue repair
GO Annotations:  Associated to 1 GO processes
GO:0042246 tissue regeneration IEP
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy; CADASIL
Synonyms: Hereditary multi-infarct dementia [Orphanet: ORPHA136]
OMIM: 125310
Orphanet: ORPHA136
Disease:  Lateral meningocele syndrome; LMNS
OMIM: 130720
Orphanet: ORPHA2789
Disease:  Myofibromatosis, infantile, 2; IMF2
Synonyms: Infantile myofibromatosis [Orphanet: ORPHA2591]
OMIM: 615293
Orphanet: ORPHA2591


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1. Gurney AL, Hoey TC, van der Horst ETH, Sato AK, Liu YC, Bruhns MF, Lewicki JA. (2012) Antibodies to notch receptors. Patent number: US8226943 B2. Assignee: Oncomed Pharmaceuticals, Inc.. Priority date: 08/07/2008. Publication date: 24/07/2012.

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