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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 1 | 2321 | 19p13.12 | NOTCH3 | notch receptor 3 | |
Mouse | 1 | 2318 | 17 17.37 cM | Notch3 | notch 3 | |
Rat | 1 | 2319 | 7q11 | Notch3 | notch receptor 3 |
Previous and Unofficial Names ![]() |
CADASIL | CASIL | IMF2 | notch 3 | Notch homolog 3 (Drosophila) |
Database Links ![]() |
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Alphafold | Q9UM47 (Hs), Q61982 (Mm), Q9R172 (Rn) |
CATH/Gene3D | 1.25.40.20 |
ChEMBL Target | CHEMBL3407319 (Hs) |
Ensembl Gene | ENSG00000074181 (Hs), ENSMUSG00000038146 (Mm), ENSRNOG00000004346 (Rn) |
Entrez Gene | 4854 (Hs), 18131 (Mm), 56761 (Rn) |
Human Protein Atlas | ENSG00000074181 (Hs) |
KEGG Gene | hsa:4854 (Hs), mmu:18131 (Mm), rno:56761 (Rn) |
OMIM | 600276 (Hs) |
Pharos | Q9UM47 (Hs) |
RefSeq Nucleotide | NM_000435 (Hs), NM_008716 (Mm), NM_020087 (Rn) |
RefSeq Protein | NP_000426 (Hs), NP_064472 (Rn) |
UniProtKB | Q9UM47 (Hs), Q61982 (Mm), Q9R172 (Rn) |
Wikipedia | NOTCH3 (Hs) |
Download all structure-activity data for this target as a CSV file
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Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Immuno Process Associations | ||
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Clinically-Relevant Mutations and Pathophysiology ![]() |
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1. Gurney AL, Hoey TC, van der Horst ETH, Sato AK, Liu YC, Bruhns MF, Lewicki JA. (2012) Antibodies to notch receptors. Patent number: US8226943 B2. Assignee: Oncomed Pharmaceuticals, Inc.. Priority date: 08/07/2008. Publication date: 24/07/2012.