Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	386	11q13.4	PPME1	protein phosphatase methylesterase 1
Mouse	-	386	7 E2	Ppme1	protein phosphatase methylesterase 1
Rat	-	386	1q32	Ppme1	protein phosphatase methylesterase 1

Previous and Unofficial Names

PME1 | PME-1

Database Links
Alphafold	Q9Y570 (Hs), Q8BVQ5 (Mm), Q4FZT2 (Rn)
BRENDA	3.1.1.89
CATH/Gene3D	3.40.50.1820
ChEMBL Target	CHEMBL1293320 (Hs), CHEMBL2189138 (Mm)
Ensembl Gene	ENSG00000214517 (Hs), ENSMUSG00000030718 (Mm), ENSRNOG00000017227 (Rn)
Entrez Gene	51400 (Hs), 72590 (Mm), 361613 (Rn)
Human Protein Atlas	ENSG00000214517 (Hs)
KEGG Enzyme	3.1.1.89
KEGG Gene	hsa:51400 (Hs), mmu:72590 (Mm), rno:361613 (Rn)
OMIM	611117 (Hs)
Pharos	Q9Y570 (Hs)
RefSeq Nucleotide	NM_001271593 (Hs), NM_028292 (Mm), NM_001191838 (Rn)
RefSeq Protein	NP_001258522 (Hs), NP_082568 (Mm), NP_001178767 (Rn)
UniProtKB	Q9Y570 (Hs), Q8BVQ5 (Mm), Q4FZT2 (Rn)
Wikipedia	PPME1 (Hs)

Enzyme Reaction
EC Number: 3.1.1.89

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference ABL127 Hs Inhibition 7.9 – 8.0 pIC50 1-2 ⤷ pIC50 8.0 (IC50 1x10-8 M) [2] pIC50 7.9 (IC50 1.2x10-8 M) [1]