cryptochrome circadian regulator 1 | Circadian clock proteins | IUPHAR/BPS Guide to PHARMACOLOGY

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cryptochrome circadian regulator 1

Target not currently curated in GtoImmuPdb

Target id: 2876

Nomenclature: cryptochrome circadian regulator 1

Family: Circadian clock proteins

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 586 12q23-q24.1 CRY1 cryptochrome circadian regulator 1
Mouse - 606 10 C Cry1 cryptochrome 1 (photolyase-like)
Rat - 588 7q13 Cry1 cryptochrome circadian regulator 1
Previous and Unofficial Names
cryptochrome 1 (photolyase-like) | cryptochrome circadian clock 1 | PHLL1
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
KL044 Hs Binding 7.2 pEC50 1
pEC50 7.2 (EC50 6.3x10-8 M) [1]
Immuno Process Associations
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 2 GO processes
GO:0031397 negative regulation of protein ubiquitination ISS
GO:0031398 positive regulation of protein ubiquitination ISS


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1. Lee JW, Hirota T, Kumar A, Kim NJ, Irle S, Kay SA. (2015) Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock. ChemMedChem, 10 (9): 1489-97. [PMID:26174033]

How to cite this page

Circadian clock proteins: cryptochrome circadian regulator 1. Last modified on 28/11/2017. Accessed on 18/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY,