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ectonucleoside triphosphate diphosphohydrolase 2

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Target not currently curated in GtoImmuPdb

Target id: 2889

Nomenclature: ectonucleoside triphosphate diphosphohydrolase 2

Abbreviated Name: NTPDase-2

Systematic Nomenclature: CD39L1

Family: Hydrolases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 2 495 9q34.3 ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 3
Mouse 2 495 2 A3 Entpd2 ectonucleoside triphosphate diphosphohydrolase 2
Rat 2 495 3p13 Entpd2 ectonucleoside triphosphate diphosphohydrolase 2
Previous and Unofficial Names Click here for help
CD39 antigen-like 1 | CD39L1 | ecto-ATPase 2 | NTPDase 2 | NTPDase-2
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number: 3.6.1.-
Description Reaction Reference
Hydrolyzes extracellular nucleotide 5'-triphosphates NTP>NMP + 2 phosphate

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
PSB-6426 Small molecule or natural product Primary target of this compound Hs Inhibition 5.1 pKi 1
pKi 5.1 (Ki 8.2x10-6 M) [1]
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 3 GO processes
GO:0035457 cellular response to interferon-alpha IEP
GO:0071354 cellular response to interleukin-6 ISO
GO:0071356 cellular response to tumor necrosis factor IEP
General Comments
ENTPD2 preferentially hydrolyses nucleoside triphosphates over nucleoside diphosphates [2-3].


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1. Brunschweiger A, Iqbal J, Umbach F, Scheiff AB, Munkonda MN, Sévigny J, Knowles AF, Müller CE. (2008) Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide. J Med Chem, 51 (15): 4518-28. [PMID:18630897]

2. Knowles AF, Chiang WC. (2003) Enzymatic and transcriptional regulation of human ecto-ATPase/E-NTPDase 2. Arch Biochem Biophys, 418 (2): 217-27. [PMID:14522593]

3. Mateo J, Harden TK, Boyer JL. (1999) Functional expression of a cDNA encoding a human ecto-ATPase. Br J Pharmacol, 128 (2): 396-402. [PMID:10510450]

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