mGlu<sub>4</sub> receptor | Metabotropic glutamate receptors | IUPHAR/BPS Guide to PHARMACOLOGY

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mGlu4 receptor

Target not currently curated in GtoImmuPdb

Target id: 292

Nomenclature: mGlu4 receptor

Family: Metabotropic glutamate receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
class C G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 912 6p21.3 GRM4 glutamate metabotropic receptor 4 17,35,41,62-63
Mouse 7 832 17 A3.3 Grm4 glutamate receptor, metabotropic 4
Rat 7 912 20p12 Grm4 glutamate metabotropic receptor 4 39,50
Gene and Protein Information Comments
The mouse sequence is provisional and has not been confirmed.
Previous and Unofficial Names
mGluR4 | GPRC1D | glutamate receptor
Database Links
Specialist databases
GPCRDB grm4_human (Hs), grm4_mouse (Mm), grm4_rat (Rn)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Natural/Endogenous Ligands
L-glutamic acid
Comments: Other endogenous ligands include L-aspartic acid, L-serine-O-phosphate, NAAG and L-cysteine sulphinic acid

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
[3H]AP4 Rn Full agonist 6.3 pKd 23
pKd 6.3 [23]
L-glutamic acid Rn Full agonist 4.9 – 5.5 pKi 2,23,53-54
pKi 4.9 – 5.5 [2,23,53-54]
FP0429 Hs Full agonist 7.3 – 7.4 pEC50 18
pEC50 7.3 – 7.4 [18]
LSP4-2022 Hs Agonist 7.0 pEC50 22
pEC50 7.0 (EC50 1.1x10-7 M) [22]
L-AP4 Hs Agonist 6.5 pEC50 63
pEC50 6.5 (EC50 3.2x10-7 M) [63]
L-serine-O-phosphate Hs Agonist 5.9 pEC50 63
pEC50 5.9 (EC50 1.42x10-6 M) [63]
LSP1-2111 Rn Agonist 5.7 pEC50 6
pEC50 5.7 (EC50 2.2x10-6 M) [6]
(R,S)-4-PPG Hs Full agonist 5.3 pEC50 19-20
pEC50 5.3 [19-20]
L-glutamic acid Hs Agonist 4.7 – 5.5 pEC50 44
pEC50 4.7 – 5.5 [44]
(S)-3,4-DCPG Hs Full agonist 5.1 pEC50 52
pEC50 5.1 [52]
ACPT-I Rn Full agonist 5.1 pEC50 1
pEC50 5.1 [1]
L-AP4 Rn Full agonist 6.0 – 6.4 pIC50 16,23,51,54
pIC50 6.0 – 6.4 [16,23,51,54]
L-serine-O-phosphate Rn Full agonist 5.4 – 6.2 pIC50 16,23,51,54-55
pIC50 5.4 – 6.2 [16,23,51,54-55]
L-CCG-I Rn Full agonist 4.3 – 5.0 pIC50 25
pIC50 4.3 – 5.0 [25]
View species-specific agonist tables
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
CPPG Rn Antagonist 4.6 pKi 23
pKi 4.6 [23]
MAP4 Rn Antagonist 4.6 pKi 23
pKi 4.6 [23]
MPPG Rn Antagonist 4.2 pKi 23
pKi 4.2 [23]
LY341495 Hs Antagonist 4.7 pIC50 30
pIC50 4.7 [30]
View species-specific antagonist tables
Allosteric Modulators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ADX88178 Hs Positive 7.4 pKi 33
pKi 7.4 (Ki 3.9x10-8 M) [33]
ADX88178 Hs Positive 8.5 pEC50 33
pEC50 8.5 (EC50 3.5x10-9 M) [33]
compound 22a [PMID: 21688779] Hs Positive 8.1 pEC50 26
pEC50 8.1 (EC50 9x10-9 M) [26]
ADX88178 Rn Positive 8.0 pEC50 33
pEC50 8.0 (EC50 9.1x10-9 M) [33]
VU2957 Hs Positive 7.2 pEC50 42
pEC50 7.2 (EC50 6.44x10-8 M) [42]
foliglurax Hs Positive 7.1 pEC50 10
pEC50 7.1 (EC50 7.6x10-8 M) [10]
Description: Calcium assay using human mGluR4.
compound 1 [PMID: 22465637] Hs Positive 6.7 pEC50 27
pEC50 6.7 (EC50 2.2x10-7 M) [27]
VU0361737 Hs Positive 6.6 pEC50 15
pEC50 6.6 (EC50 2.4x10-7 M) [15]
SIB-1893 Hs Positive 6.3 – 6.8 pEC50 36
pEC50 6.3 – 6.8 (EC50 4.7x10-7 – 1.5x10-7 M) obtained in the presence of L-AP4 [36]
VU0400195 Hs Positive 6.5 pEC50 29
pEC50 6.5 (EC50 2.91x10-7 M) [29]
VU0364770 Rn Positive 6.5 pEC50 28
pEC50 6.5 (EC50 2.9x10-7 M) [28]
MPEP Hs Positive 6.3 – 6.6 pEC50 36
pEC50 6.3 – 6.6 (EC50 5.5x10-7 – 2.6x10-7 M) obtained in the presence of L-AP4 [36]
VU0359516 Hs Positive 6.4 pEC50 61
pEC50 6.4 (EC50 3.8x10-7 M) [61]
VU0400195 Rn Positive 6.4 pEC50 29
pEC50 6.4 (EC50 3.76x10-7 M) [29]
Lu AF21934 Hs Positive 6.3 pEC50 5
pEC50 6.3 (EC50 5x10-7 M) [5]
VU0001171 Hs Positive 6.2 pEC50 60
pEC50 6.2 (EC50 6.5x10-7 M) [60]
VU0155041 Hs Positive 6.1 pEC50 37
pEC50 6.1 (EC50 7.98x10-7 M) [37]
compound 7 [PMID: 20638279] Hs Positive 6.0 pEC50 14
pEC50 6.0 (EC50 1x10-6 M) [14]
VU0364770 Hs Positive 6.0 pEC50 28
pEC50 6.0 (EC50 1.1x10-6 M) [28]
compound 11 [PMID: 20638279] Hs Positive 6.0 pEC50 14
pEC50 6.0 (EC50 1x10-6 M) [14]
VU0092145 Hs Positive 5.5 – 5.7 pEC50 60
pEC50 5.5 – 5.7 (EC50 3x10-6 – 1.8x10-6 M) [60]
VU0080241 Hs Positive 5.3 pEC50 38
pEC50 5.3 (EC50 4.6x10-6 M) [38]
PHCCC Hs Positive 4.5 pEC50 34
pEC50 4.5 obtained in the presence of L-AP4 [34]
View species-specific allosteric modulator tables
Allosteric Modulator Comments
pEC50 values for MPEP and SIB-1893 were obtained in the presence of L-AP4 [36]. 4-PAM2 was reported in [33] as a radioligand, but no affinity was given.
Primary Transduction Mechanisms
Transducer Effector/Response
Gi/Go family Adenylate cyclase inhibition
References:  45,47
Tissue Distribution
Species:  Human
Technique:  RT-PCR.
References:  49
CNS: cerebellum, globus pallidus > substantia nigra pars reticulata, entopeduncular nucleus, striatum, hippocampus, neocortex, thalamus.
Species:  Mouse
Technique:  immunocytochemistry.
References:  9
CNS: cerebellar cortex, globus pallidus, ventral pallidum > olfactory tubercle, striatum, entopeduncular nucleus, sensory relay nuclei of the thalamus, medial and dorsolateral geniculate nuclei, substantia nigra, spinal trigeminal nucleus > neocortex layers I-III and V, piriform cortex, hippocampus, lateral and basolateral amygdaloid nuclei, superficial grey of the superior colliculus.
Species:  Mouse
Technique:  immunocytochemistry.
References:  13
Presynaptic active zone of GABAergic axon terminals.
Species:  Rat
Technique:  immunocytochemistry.
References:  9,31
Presynaptic active zone of excitatory axon terminals.
Species:  Rat
Technique:  immunocytochemistry.
References:  13
Retina (cell bodies of ganglion cells).
Species:  Rat
Technique:  Northern Blotting and in situ hybridisation.
References:  3
Species:  Rat
Technique:  in situ hybridisation.
References:  24
Taste buds.
Species:  Rat
Technique:  in situ hybridisation.
References:  11-12,56
CNS: cerebellar cortex, main olfactory bulb, medial septal nucleus, mammillary nuclei > accessory olfactory bulb, olfactory tubercle, subthalamic nucleus, thalamus, pontine nuclei > neocortex, hippocampus, bed nucleus of the stria terminalis, basolateral amygdaloid nucleus, striatum, nuclues accumbens, interpeduncular nucleus, superior collicus, red nucleus, oculomotor nucleus, trochlear nucleus, periacqueductal gray.
Species:  Rat
Technique:  in situ hybridisation.
References:  40
Pancreatic islets of Langerhans (alpha and F cells).
Species:  Rat
Technique:  RT-PCR.
References:  57
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays
Measurement of intracellular calcium levels in HEK cells transfected with the rat mGlu4 receptor and G15 and loaded with a calcium-sensitive dye, Fluo-4 (see comments).
Species:  Rat
Tissue:  HEK cells.
Response measured:  L-AP4-induced release of intracellular calcium.
References:  46
Measurement of intracellular calcium levels in CHO cells transfected with the human mGlu4 receptor as well as a promiscuous/chimeric G-protein comprising Gq with five amino acids from the C-terminal replaced with those from Gi3.
The calcium-mobilization assays are compatible with the fluorometric imaging plate reader formats.
Species:  Human
Tissue:  CHO cells.
Response measured:  Mobilisation of intracellular calcium.
References:  32
Measurement of cAMP levels in CHO cells transfected with the rat mGlu4 receptor.
Species:  Rat
Tissue:  CHO cells
Response measured:  Inhibition of cAMP production.
References:  51
Measurement of IP levels in HEK 293 cells transfected with the rat mGlu4 receptor and the chimeric G-protein Gqi9.
Species:  Rat
Tissue:  HEK 293 cells,
Response measured:  Stimulation of IP production.
References:  8
Functional Assay Comments
Functional responses for a series of chimeras between mGlu4/mGlu6 and mGlu4/mGlu7 led to the identification of key amino acid residues that elucidate the disperson of agonist affinities for the group III receptors mGlu4, mGluR6 and mGlu7.
Physiological Functions
In addition to the taste-mGlu4 receptor, brain-mGlu4 may be important for the sensation of glutamate taste ("umami") in rat tongue.
Species:  Rat
Tissue:  Tongue
References:  11-12,56
Conditioned taste aversion (CTA) experiments were performed to show that L-AP4 (mGlu4 agonist) mimics the taste of monosodium glutamate (MSG) ("umami" taste sense) on the rat tongue.
Species:  Rat
Tissue:  In vivo.
References:  12
Physiological Consequences of Altering Gene Expression
It was found that mGlu4 knockout mice had altered spatial learning and memory when compared against wild-type mice. These knockout mise also displaced a resistance to chemically-induced absence seizures likely mediated by alterations in glutamamte and GABA release in the thalamus. The mGlu4 knockout mice also do not show the motor stimulatory effect of ethanol.
Species:  Mouse
Technique:  Gene targeting in embryonic stem cells.
References:  7,21,48,59
It was shown that mGlu4 knockout mice, while having normal spontaneous motor activities, were deficient in learning complex motor tasks.
Species:  Mouse
Technique:  Gene targeting in embryonic stem cells.
References:  43
Agonists of mGlu4 modulate excitatory transmission in dopamine neurons and reduce neuronal degeneration in rodent Parkinsonian models.
Species:  Mouse
Technique:  Gene targeting in embryonic stem cells.
References:  4,58
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Grm4tm1Hpn Grm4tm1Hpn/Grm4tm1Hpn
involves: 129S1/Sv * 129X1/SvJ * CD-1
MGI:1351341  MP:0002804 abnormal motor learning PMID: 8815915 
Grm4tm1Hpn Grm4tm1Hpn/Grm4tm1Hpn
involves: 129S1/Sv * 129X1/SvJ * CD-1
MGI:1351341  MP:0002920 decreased paired-pulse facilitation PMID: 8815915 
Grm4tm1Hpn Grm4tm1Hpn/Grm4tm1Hpn
involves: 129S1/Sv * 129X1/SvJ * CD-1
MGI:1351341  MP:0002922 decreased post-tetanic potentiation PMID: 8815915 
Biologically Significant Variants
Type:  Naturally occurring mutation
Species:  Rat
Description:  A truncated form of the mGlu4 receptor, taste-mGlu4, which lacks approximately 50% of the extracellular amino terminus of the full-length mGlu4 receptor, was found to impart glutamate taste ("umami") in rat taste buds. As for the mGlu4(b) variant, there is no strong data supporting the existence of this variant.
References:  11-12
Type:  Splice variant
Species:  Rat
Description:  A variant of mGlu4(a), called mGlu4(b) has been reported that would have 135 different residues replacing the entire C-terminal tail of mGlu4(a). However, the existence of this variant has not been confirmed by RT-PCR analysis, and the human genome sequence did not reveal the presence of consensus donor and acceptor splice sites possibly responsible for the generation of this mGlu4(b) variant.
References:  13,54


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Francine Acher, P. Jeffrey Conn, Robert Duvoisin, Francesco Ferraguti, Peter J. Flor, David Hampson, Michael P. Johnson, James Monn, Shigetada Nakanishi, Ferdinando Nicoletti, Jean-Philippe Pin, Darryle D. Schoepp, Ryuichi Shigemoto.
Metabotropic glutamate receptors: mGlu4 receptor. Last modified on 14/11/2018. Accessed on 23/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY,