Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	2	109	6q27	MPC1	mitochondrial pyruvate carrier 1	1,4
Mouse	2	109	17 4.92 cM	Mpc1	mitochondrial pyruvate carrier 1	1,4
Rat	2	109	1q12	Mpc1	mitochondrial pyruvate carrier 1

Previous and Unofficial Names

brain protein 44-like | BRP44L | CGI-129 | apoptosis-regulating basic protein | ARBP | solute carrier family 54 member 1 | SLC54A1

Database Links
Specialist databases
Bioparadigms SLC Tables	SLC54A1 (Hs)
RESOLUTE	MPC1 (Hs)
Other databases
Alphafold	Q9Y5U8 (Hs), P63030 (Mm), P63031 (Rn)
Ensembl Gene	ENSG00000060762 (Hs), ENSMUSG00000023861 (Mm), ENSRNOG00000012415 (Rn)
Entrez Gene	51660 (Hs), 55951 (Mm), 171087 (Rn)
Human Protein Atlas	ENSG00000060762 (Hs)
KEGG Gene	hsa:51660 (Hs), mmu:55951 (Mm), rno:171087 (Rn)
Pharos	Q9Y5U8 (Hs)
UniProtKB	Q9Y5U8 (Hs), P63030 (Mm), P63031 (Rn)
Wikipedia	MPC1 (Hs)

Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference Pyruvate N/A - - 1,4

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference UK-5099 Rn Inhibition 7.3 pIC50 3 ⤷ pIC50 7.3 (IC50 5x10-8 M) [3] α-cyanocinnamate Rn Inhibition 6.7 pIC50 3 ⤷ pIC50 6.7 (IC50 2x10-7 M) [3] α-Cyano-5-phenyl-2,4-pentadienic acid Rn Inhibition 6.7 pIC50 3 ⤷ pIC50 6.7 (IC50 2x10-7 M) [3] mitoglitazone Mm Inhibition 5.9 pIC50 2 ⤷ pIC50 5.9 (IC50 1.3x10-6 M) [2] α-cyano-4-hydroxycinnamate Rn Inhibition 5.8 pIC50 3 ⤷ pIC50 5.8 (IC50 1.5x10-6 M) [3]
View species-specific inhibitor tables

Immuno Process Associations

Immuno Process:  Cytokine production & signalling

Clinically-Relevant Mutations and Pathophysiology
Disease:  Mitochondrial pyruvate carrier deficiency Synonyms: Familial atrial fibrillation [Orphanet: ORPHA334] Disease Ontology: DOID:0080363 OMIM: 614741 Orphanet: ORPHA447784, ORPHA334

General Comments
MPC1 forms an ~150kDa oligomeric complex with MPC2. This protein complex (the mitochondrial pyruvate carrier) is involved in the transport of pyruvate across the inner membrane of mitochondria, into the mitochondrial matrix for oxidative phosphorylation.