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Target not currently curated in GtoImmuPdb
Target id: 3022
Nomenclature: mitochondrial pyruvate carrier 1
Systematic Nomenclature: SLC54A1
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 2 | 109 | 6q27 | MPC1 | mitochondrial pyruvate carrier 1 | 1,5 |
Mouse | 2 | 109 | 17 4.92 cM | Mpc1 | mitochondrial pyruvate carrier 1 | 1,5 |
Rat | 2 | 109 | 1q12 | Mpc1 | mitochondrial pyruvate carrier 1 |
Previous and Unofficial Names ![]() |
brain protein 44-like | BRP44L | CGI-129 | apoptosis-regulating basic protein | ARBP | solute carrier family 54 member 1 | SLC54A1 |
Database Links ![]() |
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Specialist databases | |
Bioparadigms SLC Tables | SLC54A1 (Hs) |
Other databases | |
Ensembl Gene | ENSG00000060762 (Hs), ENSMUSG00000023861 (Mm), ENSRNOG00000012415 (Rn) |
Entrez Gene | 51660 (Hs), 55951 (Mm), 171087 (Rn) |
Human Protein Atlas | ENSG00000060762 (Hs) |
KEGG Gene | hsa:51660 (Hs), mmu:55951 (Mm), rno:171087 (Rn) |
Pharos | Q9Y5U8 (Hs) |
UniProtKB | Q9Y5U8 (Hs), P63030 (Mm), P63031 (Rn) |
Wikipedia | MPC1 (Hs) |
Substrates and Reaction Kinetics ![]() |
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Download all structure-activity data for this target as a CSV file
Antagonists | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Immuno Process Associations | ||||||||||||
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Clinically-Relevant Mutations and Pathophysiology ![]() |
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General Comments |
MPC1 forms an ~150kDa oligomeric complex with MPC2. This protein complex (the mitochondrial pyruvate carrier) is involved in the transport of pyruvate across the inner membrane of mitochondria, into the mitochondrial matrix for oxidative phosphorylation. |
1. Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, Cardon CM, Van Vranken JG, Dephoure N et al.. (2012) A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science, 337 (6090): 96-100. [PMID:22628558]
2. Colca JR, McDonald WG, Cavey GS, Cole SL, Holewa DD, Brightwell-Conrad AS, Wolfe CL, Wheeler JS, Coulter KR, Kilkuskie PM et al.. (2013) Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins. PLoS One, 8 (5): e61551. [PMID:23690925]
3. Divakaruni AS, Wiley SE, Rogers GW, Andreyev AY, Petrosyan S, Loviscach M, Wall EA, Yadava N, Heuck AP, Ferrick DA et al.. (2013) Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proc Natl Acad Sci U S A, 110 (14): 5422-7. [PMID:23513224]
4. Halestrap AP. (1975) The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors. Biochem J, 148 (1): 85-96. [PMID:1156402]
5. Herzig S, Raemy E, Montessuit S, Veuthey JL, Zamboni N, Westermann B, Kunji ER, Martinou JC. (2012) Identification and functional expression of the mitochondrial pyruvate carrier. Science, 337 (6090): 93-6. [PMID:22628554]