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mitochondrial pyruvate carrier 1

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Target not currently curated in GtoImmuPdb

Target id: 3022

Nomenclature: mitochondrial pyruvate carrier 1

Systematic Nomenclature: SLC54A1

Family: SLC54 Mitochondrial pyruvate carriers

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 2 109 6q27 MPC1 mitochondrial pyruvate carrier 1 1,5
Mouse 2 109 17 4.92 cM Mpc1 mitochondrial pyruvate carrier 1 1,5
Rat 2 109 1q12 Mpc1 mitochondrial pyruvate carrier 1
Previous and Unofficial Names Click here for help
brain protein 44-like | BRP44L | CGI-129 | apoptosis-regulating basic protein | ARBP | solute carrier family 54 member 1 | SLC54A1
Database Links Click here for help
Specialist databases
Bioparadigms SLC Tables SLC54A1 (Hs)
Other databases
Ensembl Gene ENSG00000060762 (Hs), ENSMUSG00000023861 (Mm), ENSRNOG00000012415 (Rn)
Entrez Gene 51660 (Hs), 55951 (Mm), 171087 (Rn)
Human Protein Atlas ENSG00000060762 (Hs)
KEGG Gene hsa:51660 (Hs), mmu:55951 (Mm), rno:171087 (Rn)
Pharos Q9Y5U8 (Hs)
UniProtKB Q9Y5U8 (Hs), P63030 (Mm), P63031 (Rn)
Wikipedia MPC1 (Hs)
Substrates and Reaction Kinetics Click here for help
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
Pyruvate N/A - - 1,5

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Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
UK-5099 Small molecule or natural product Click here for species-specific activity table Rn Antagonist 7.3 pIC50 1-2,4
⤷ pIC50 7.3 (IC50 5x10-8 M) [1-2,4]
α-cyanocinnamate Small molecule or natural product Click here for species-specific activity table Rn Antagonist 6.7 pIC50 4
⤷ pIC50 6.7 (IC50 2x10-7 M) [4]
α-Cyano-5-phenyl-2,4-pentadienic acid Small molecule or natural product Click here for species-specific activity table Rn Antagonist 6.7 pIC50 4
⤷ pIC50 6.7 (IC50 2x10-7 M) [4]
mitoglitazone Small molecule or natural product Click here for species-specific activity table Mm Antagonist 5.9 pIC50 3
⤷ pIC50 5.9 (IC50 1.3x10-6 M) [3]
α-cyano-4-hydroxycinnamate Small molecule or natural product Click here for species-specific activity table Rn Antagonist 5.8 pIC50 4
⤷ pIC50 5.8 (IC50 1.5x10-6 M) [4]
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:1990830 cellular response to leukemia inhibitory factor IEA
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Mitochondrial pyruvate carrier deficiency
Synonyms: Familial atrial fibrillation [Orphanet: ORPHA334]
Disease Ontology: DOID:0080363
OMIM: 614741
Orphanet: ORPHA447784, ORPHA334
General Comments
MPC1 forms an ~150kDa oligomeric complex with MPC2. This protein complex (the mitochondrial pyruvate carrier) is involved in the transport of pyruvate across the inner membrane of mitochondria, into the mitochondrial matrix for oxidative phosphorylation.

References

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1. Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, Cardon CM, Van Vranken JG, Dephoure N et al.. (2012) A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science, 337 (6090): 96-100. [PMID:22628558]

2. Colca JR, McDonald WG, Cavey GS, Cole SL, Holewa DD, Brightwell-Conrad AS, Wolfe CL, Wheeler JS, Coulter KR, Kilkuskie PM et al.. (2013) Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins. PLoS One, 8 (5): e61551. [PMID:23690925]

3. Divakaruni AS, Wiley SE, Rogers GW, Andreyev AY, Petrosyan S, Loviscach M, Wall EA, Yadava N, Heuck AP, Ferrick DA et al.. (2013) Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proc Natl Acad Sci U S A, 110 (14): 5422-7. [PMID:23513224]

4. Halestrap AP. (1975) The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors. Biochem J, 148 (1): 85-96. [PMID:1156402]

5. Herzig S, Raemy E, Montessuit S, Veuthey JL, Zamboni N, Westermann B, Kunji ER, Martinou JC. (2012) Identification and functional expression of the mitochondrial pyruvate carrier. Science, 337 (6090): 93-6. [PMID:22628554]

Contributors

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