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SLC54 Mitochondrial pyruvate carriers C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Pyruvate is oxidized to acetyl‐CoA by pyruvate dehydrogenase which is localized in the mitochondrial matrix. The mitochondrial pyruvate carrier (MPC) is composed of SLC54 family members (MPC1 and MPC2) [1,4], which form functional hetero-dimers [7-8]. The MPC is expressed in the inner mitochondrial membrane and involved in the import of pyruvate into mitochondria [1,4]. Ubiquitous disruption of either MPC1 or MPC2 expression results in embryonic lethality [10-11]. Clinically relevant concentrations of the insulin sensitizers, thiazolidinediones, inhibit the MPC [2]. Other clinically relevant inhibitors of the MPC complex are lonidamine [6-7], quinolone antibacterials [5], entacapone and nitrofurantoin [7].

Transporters

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mitochondrial pyruvate carrier 1 / SLC54A1 C Show summary » More detailed page go icon to follow link

mitochondrial pyruvate carrier 2 / SLC54A2 C Show summary » More detailed page go icon to follow link

mitochondrial pyruvate carrier 1 like / SLC54A3 C Show summary » More detailed page go icon to follow link

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Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.