SLC54 Mitochondrial pyruvate carriers | Transporters | IUPHAR/BPS Guide to PHARMACOLOGY

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SLC superfamily of solute carriers
SLC54 Mitochondrial pyruvate carriers

SLC54 Mitochondrial pyruvate carriers C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Transporters

mitochondrial pyruvate carrier 1 / SLC54A1 C Show summary »« Hide summary

Target Id

3022

Nomenclature

mitochondrial pyruvate carrier 1

Systematic nomenclature

SLC54A1

Previous and unofficial names

brain protein 44-like | BRP44L | CGI-129

Genes

MPC1 (Hs), Mpc1 (Mm), Mpc1 (Rn)

Ensembl ID

ENSG00000060762 (Hs), ENSMUSG00000023861 (Mm), ENSRNOG00000012415 (Rn)

UniProtKB AC

Q9Y5U8 (Hs), P63030 (Mm), P63031 (Rn)

Substrates

Pyruvate [1-2]

Comment

SLC54A1 is ubiquitously expressed [3].

mitochondrial pyruvate carrier 2 / SLC54A2 C Show summary »« Hide summary

Target Id

3023

Nomenclature

mitochondrial pyruvate carrier 2

Systematic nomenclature

SLC54A2

Previous and unofficial names

brain protein 44 | BRP44 | solute carrier family 54 member 2

Genes

MPC2 (Hs), Mpc2 (Mm), Mpc2 (Rn)

Ensembl ID

ENSG00000143158 (Hs), ENSMUSG00000026568 (Mm), ENSRNOG00000003150 (Rn)

UniProtKB AC

O95563 (Hs), Q9D023 (Mm), P38718 (Rn)

Substrates

Pyruvate [1]

Comment

SLC54A2 is ubiquitously expressed [3].

mitochondrial pyruvate carrier 1 like / SLC54A3 C Show summary »« Hide summary

Target Id

3024

Nomenclature

mitochondrial pyruvate carrier 1 like

Systematic nomenclature

SLC54A3

Genes

MPC1L (Hs), Mpc1l (Rn)

Ensembl ID

ENSG00000238205 (Hs)

UniProtKB AC

P0DKB6 (Hs)

Substrates

Pyruvate [3]

Comment

SLC54A3 is expressed in testis, postmeiotic spermatids and sperm cells [3].

Comments

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References

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1. Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, Cardon CM, Van Vranken JG, Dephoure N et al.. (2012) A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science, 337 (6090): 96-100. [PMID:22628558]

2. Herzig S, Raemy E, Montessuit S, Veuthey JL, Zamboni N, Westermann B, Kunji ER, Martinou JC. (2012) Identification and functional expression of the mitochondrial pyruvate carrier. Science, 337 (6090): 93-6. [PMID:22628554]

3. Vanderperre B, Cermakova K, Escoffier J, Kaba M, Bender T, Nef S, Martinou JC. (2016) MPC1-like Is a Placental Mammal-specific Mitochondrial Pyruvate Carrier Subunit Expressed in Postmeiotic Male Germ Cells. J. Biol. Chem., 291 (32): 16448-61. [PMID:27317664]

How to cite this family page

Database page citation:

SLC54 Mitochondrial pyruvate carriers. Accessed on 09/04/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1006.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.

SLC54 Mitochondrial pyruvate carriers C

Transporters

Comments

Further reading

References

How to cite this family page