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mitochondrial pyruvate carrier 2

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Target not currently curated in GtoImmuPdb

Target id: 3023

Nomenclature: mitochondrial pyruvate carrier 2

Systematic Nomenclature: SLC54A2

Family: SLC54 Mitochondrial pyruvate carriers

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 3 127 1q24.2 MPC2 mitochondrial pyruvate carrier 2 1,5
Mouse 3 127 1 H2.2 Mpc2 mitochondrial pyruvate carrier 2 1,5
Rat 3 127 13q23 Mpc2 mitochondrial pyruvate carrier 2
Previous and Unofficial Names Click here for help
brain protein 44 | BRP44 | solute carrier family 54 member 2 | SLC54A2
Database Links Click here for help
Specialist databases
RESOLUTE MPC2 (Hs)
Other databases
Alphafold
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Substrates and Reaction Kinetics Click here for help
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
Pyruvate N/A - - 1,5

Download all structure-activity data for this target as a CSV file go icon to follow link

Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
UK-5099 Small molecule or natural product Click here for species-specific activity table Rn Antagonist 7.3 pIC50 1-2,4
pIC50 7.3 (IC50 5x10-8 M) [1-2,4]
α-cyanocinnamate Small molecule or natural product Click here for species-specific activity table Rn Antagonist 6.7 pIC50 4
pIC50 6.7 (IC50 2x10-7 M) [4]
α-Cyano-5-phenyl-2,4-pentadienic acid Small molecule or natural product Click here for species-specific activity table Rn Antagonist 6.7 pIC50 4
pIC50 6.7 (IC50 2x10-7 M) [4]
mitoglitazone Small molecule or natural product Click here for species-specific activity table Mm Antagonist 5.9 pIC50 3
pIC50 5.9 (IC50 1.3x10-6 M) [3]
α-cyano-4-hydroxycinnamate Small molecule or natural product Click here for species-specific activity table Rn Antagonist 5.8 pIC50 4
pIC50 5.8 (IC50 1.5x10-6 M) [4]
General Comments
MPC2 forms an ~150kDa oligomeric complex with MPC1. This protein complex (the mitochondrial pyruvate carrier) is involved in the transport of pyruvate across the inner membrane of mitochondria, into the mitochondrial matrix for oxidative phosphorylation

References

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1. Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, Cardon CM, Van Vranken JG, Dephoure N et al.. (2012) A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science, 337 (6090): 96-100. [PMID:22628558]

2. Colca JR, McDonald WG, Cavey GS, Cole SL, Holewa DD, Brightwell-Conrad AS, Wolfe CL, Wheeler JS, Coulter KR, Kilkuskie PM et al.. (2013) Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins. PLoS One, 8 (5): e61551. [PMID:23690925]

3. Divakaruni AS, Wiley SE, Rogers GW, Andreyev AY, Petrosyan S, Loviscach M, Wall EA, Yadava N, Heuck AP, Ferrick DA et al.. (2013) Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proc Natl Acad Sci U S A, 110 (14): 5422-7. [PMID:23513224]

4. Halestrap AP. (1975) The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors. Biochem J, 148 (1): 85-96. [PMID:1156402]

5. Herzig S, Raemy E, Montessuit S, Veuthey JL, Zamboni N, Westermann B, Kunji ER, Martinou JC. (2012) Identification and functional expression of the mitochondrial pyruvate carrier. Science, 337 (6090): 93-6. [PMID:22628554]

Contributors

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