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Target not currently curated in GtoImmuPdb
Target id: 3024
Nomenclature: mitochondrial pyruvate carrier 1 like
Systematic Nomenclature: SLC54A3
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 2 | 136 | Xp11.4 | MPC1L | mitochondrial pyruvate carrier 1 like | |
Rat | - | - | Xq12 | Mpc1l | mitochondrial pyruvate carrier 1-like |
Previous and Unofficial Names ![]() |
Brain Protein | BRP44-like protein 2 | MPC1L | MPC1LP | SLC54A3 |
Database Links ![]() |
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Specialist databases | |
Bioparadigms SLC Tables | SLC54A3 (Hs) |
RESOLUTE | MPC1L (Hs) |
Other databases | |
Alphafold | P0DKB6 (Hs) |
Ensembl Gene | ENSG00000238205 (Hs), ENSRNOG00000023163 (Rn) |
Entrez Gene | 347411 (Hs), 503429 (Rn) |
Human Protein Atlas | ENSG00000238205 (Hs) |
KEGG Gene | hsa:347411 (Hs), rno:503429 (Rn) |
Pharos | P0DKB6 (Hs) |
UniProtKB | P0DKB6 (Hs) |
Wikipedia | MPC1L (Hs) |
Substrates and Reaction Kinetics ![]() |
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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General Comments |
MPC1L is a MPC1 paralogue expressed almost exclusively in the testis of placental mammals [2]. |
1. Tavoulari S, Schirris TJJ, Mavridou V, Thangaratnarajah C, King MS, Jones DTD, Ding S, Fearnley IM, Kunji ERS. (2022) Key features of inhibitor binding to the human mitochondrial pyruvate carrier hetero-dimer. Mol Metab, 60: 101469. [PMID:35278701]
2. Vanderperre B, Cermakova K, Escoffier J, Kaba M, Bender T, Nef S, Martinou JC. (2016) MPC1-like Is a Placental Mammal-specific Mitochondrial Pyruvate Carrier Subunit Expressed in Postmeiotic Male Germ Cells. J Biol Chem, 291 (32): 16448-61. [PMID:27317664]