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target has curated data in GtoImmuPdb
Target id: 3080
Nomenclature: PVR related immunoglobulin domain containing
Abbreviated Name: PVRIG
Family: Other immune checkpoint proteins
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 3 | 326 | 7q22.1 | PVRIG | PVR related immunoglobulin domain containing | |
| Mouse | - | - | 5 G2 | Pvrig | poliovirus receptor related immunoglobulin domain containing | |
| Rat | - | - | 12q11 | Pvrig | PVR related immunoglobulin domain containing | |
| Previous and Unofficial Names |
| CD112 receptor | nectin-2 receptor | poliovirus receptor related immunoglobulin domain containing | CD112R |
| Database Links |
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| Alphafold | Q6DKI7 (Hs) |
| Ensembl Gene | ENSG00000213413 (Hs), ENSMUSG00000109713 (Mm), ENSRNOG00000051906 (Rn) |
| Entrez Gene | 79037 (Hs), 102640920 (Mm), 680923 (Rn) |
| Human Protein Atlas | ENSG00000213413 (Hs) |
| KEGG Gene | hsa:79037 (Hs), mmu:102640920 (Mm), rno:680923 (Rn) |
| OMIM | 617012 (Hs) |
| Pharos | Q6DKI7 (Hs) |
| RefSeq Nucleotide | NM_024070 (Hs) |
| RefSeq Protein | NP_076975 (Hs) |
| UniProtKB | Q6DKI7 (Hs) |
| Wikipedia | PVRIG (Hs) |
| Natural/Endogenous Ligands |
| Comments: PVRIG has been shown to interact with nectin-2 (a.k.a. PVRL2: NECTIN2; Q92692) [1]. This interaction mediates a co-inhibitory signal that blocks T cell activation/proliferation [1,3]. |
| Immunopharmacology Comments |
| PVRIG has been identified as a novel co-inhibitory immune checkpoint, that is exploited by some cancer cells to evade immune detection [1-2]. Disruption of the PVRIG/PVRL2 interaction by antagonistic anti-PVRIG antibodies reduces tumour growth in preclinical models [1]. An anti-human PVRIG monoclonal antibody called COM701 is being developed by Compugen for immuno-oncology potential in patients with advanced solid tumours- see Phase 1 clinical trial NCT03667716 which is evaluating COM701 as a monotherapy and in combination with the PD-1 checkpoint inhibitor nivolumab. |
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1. Murter B, Pan X, Ophir E, Alteber Z, Azulay M, Sen R, Levy O, Dassa L, Vaknin I, Fridman-Kfir T et al.. (2019) Mouse PVRIG Has CD8+ T Cell-Specific Coinhibitory Functions and Dampens Antitumor Immunity. Cancer Immunol Res, 7 (2): 244-256. [PMID:30659055]
2. Whelan S, Ophir E, Kotturi MF, Levy O, Ganguly S, Leung L, Vaknin I, Kumar S, Dassa L, Hansen K et al.. (2019) PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8+ T-cell Function. Cancer Immunol Res, 7 (2): 257-268. [PMID:30659054]
3. Zhu Y, Paniccia A, Schulick AC, Chen W, Koenig MR, Byers JT, Yao S, Bevers S, Edil BH. (2016) Identification of CD112R as a novel checkpoint for human T cells. J Exp Med, 213 (2): 167-76. [PMID:26755705]
Other immune checkpoint proteins: PVR related immunoglobulin domain containing. Last modified on 18/03/2019. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3080.
