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target has curated data in GtoImmuPdb
Target id: 3082
Nomenclature: LanC like 2
Abbreviated Name: LANCL2
Family: Abscisic acid receptor complex
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | 450 | 7p11.2 | LANCL2 | LanC like glutathione S-transferase 2 | 7 |
| Mouse | - | 450 | 6 B3 | Lancl2 | LanC (bacterial lantibiotic synthetase component C)-like 2 | |
| Rat | - | 450 | 4q24 | Lancl2 | LanC like glutathione S-transferase 2 | |
| Previous and Unofficial Names |
| GPR69B | LanC lantibiotic synthetase component C-like 2 (bacterial) | TASP | testis-specific adriamycin sensitivity protein |
| Database Links |
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| Alphafold | Q9NS86 (Hs), Q9JJK2 (Mm) |
| ChEMBL Target | CHEMBL3351212 (Hs), CHEMBL4802018 (Mm) |
| Ensembl Gene | ENSG00000132434 (Hs), ENSMUSG00000062190 (Mm), ENSRNOG00000006810 (Rn) |
| Entrez Gene | 55915 (Hs), 71835 (Mm), 362375 (Rn) |
| Human Protein Atlas | ENSG00000132434 (Hs) |
| KEGG Gene | hsa:55915 (Hs), mmu:71835 (Mm), rno:362375 (Rn) |
| OMIM | 612919 (Hs) |
| Pharos | Q9NS86 (Hs) |
| RefSeq Nucleotide | NM_018697 (Hs), NM_133737 (Mm), NM_001014187 (Rn) |
| RefSeq Protein | NP_061167 (Hs), NP_598498 (Mm), NP_001014209 (Rn) |
| UniProtKB | Q9NS86 (Hs), Q9JJK2 (Mm) |
| Wikipedia | LANCL2 (Hs) |
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| Immunopharmacology Comments |
| Synthetic abscisic acid analogues are hypothesised to offer anti-inflammatory and anti-diabetic potential [6,8]. The expression of LANCL2 in epithelial and immune cells suggests a potential role in modulating mucosal immune responses. To investigate this hypothesis synthetic LANCL2 modulators are being examined for potential benefit in models of inflammatory bowel disease [2-5]. |
| General Comments |
| The LANCL2 protein has been shown to bind abscisic acid, an autocrine signalling molecule that is produced by human granulocytes, and by human and murine pancreatic β cells [8]. Cellular abscisic acid signals are mediated by a membrane-associated LANCL2/CD38 complex, and evidence exists that signalling is transmitted via a pertussis toxin-sensitive Gi protein. |
1. Bruzzone S, Moreschi I, Usai C, Guida L, Damonte G, Salis A, Scarfì S, Millo E, De Flora A, Zocchi E. (2007) Abscisic acid is an endogenous cytokine in human granulocytes with cyclic ADP-ribose as second messenger. Proc Natl Acad Sci USA, 104 (14): 5759-64. [PMID:17389374]
2. Carbo A, Gandour RD, Hontecillas R, Philipson N, Uren A, Bassaganya-Riera J. (2016) An N,N-Bis(benzimidazolylpicolinoyl)piperazine (BT-11): A Novel Lanthionine Synthetase C-Like 2-Based Therapeutic for Inflammatory Bowel Disease. J Med Chem, 59 (22): 10113-10126. [PMID:27933891]
3. Leber A, Hontecillas R, Zoccoli-Rodriguez V, Bassaganya-Riera J. (2018) Activation of LANCL2 by BT-11 Ameliorates IBD by Supporting Regulatory T Cell Stability Through Immunometabolic Mechanisms. Inflamm Bowel Dis, 24 (9): 1978-1991. [PMID:29718324]
4. Leber A, Hontecillas R, Zoccoli-Rodriguez V, Chauhan J, Bassaganya-Riera J. (2019) Oral Treatment with BT-11 Ameliorates Inflammatory Bowel Disease by Enhancing Regulatory T Cell Responses in the Gut. J Immunol, 202 (7): 2095-2104. [PMID:30760618]
5. Lu P, Hontecillas R, Horne WT, Carbo A, Viladomiu M, Pedragosa M, Bevan DR, Lewis SN, Bassaganya-Riera J. (2012) Computational modeling-based discovery of novel classes of anti-inflammatory drugs that target lanthionine synthetase C-like protein 2. PLoS ONE, 7 (4): e34643. [PMID:22509338]
6. Lu P, Hontecillas R, Philipson CW, Bassaganya-Riera J. (2014) Lanthionine synthetase component C-like protein 2: a new drug target for inflammatory diseases and diabetes. Curr Drug Targets, 15 (6): 565-72. [PMID:24628287]
7. Mayer H, Pongratz M, Prohaska R. (2001) Molecular cloning, characterization, and tissue-specific expression of human LANCL2, a novel member of the LanC-like protein family. DNA Seq, 12 (3): 161-6. [PMID:11762191]
8. Sturla L, Fresia C, Guida L, Bruzzone S, Scarfì S, Usai C, Fruscione F, Magnone M, Millo E, Basile G et al.. (2009) LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells. J Biol Chem, 284 (41): 28045-57. [PMID:19667068]
Abscisic acid receptor complex: LanC like 2. Last modified on 23/04/2019. Accessed on 18/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3082.
