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LanC like 2

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 3082

Nomenclature: LanC like 2

Abbreviated Name: LANCL2

Family: Abscisic acid receptor complex

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 450 7p11.2 LANCL2 LanC like 2 7
Mouse - 450 6 B3 Lancl2 LanC (bacterial lantibiotic synthetase component C)-like 2
Rat - 450 4q24 Lancl2 LanC like 2
Previous and Unofficial Names Click here for help
GPR69B | LanC lantibiotic synthetase component C-like 2 (bacterial) | TASP | testis-specific adriamycin sensitivity protein
Database Links Click here for help
Alphafold
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
abscisic acid Small molecule or natural product Immunopharmacology Ligand Hs Binding 8.0 pKd 1
pKd 8.0 (Kd 1.1x10-8 M) [1]
Description: High affinity binding site identified using Scatchard plot analysis of [3H]ABA binding to human granulocyte plasma membranes.
BT-11 Small molecule or natural product Immunopharmacology Ligand Hs Binding 5.1 pKd 2
pKd 5.1 (Kd 7.7x10-6 M) [2]
Description: Direct binding to LANCL2 by SPR.
NSC61610 Small molecule or natural product Immunopharmacology Ligand Hs Binding - - 2,5
[2,5]
Immunopharmacology Comments
Synthetic abscisic acid analogues are hypothesised to offer anti-inflammatory and anti-diabetic potential [6,8]. The expression of LANCL2 in epithelial and immune cells suggests a potential role in modulating mucosal immune responses. To investigate this hypothesis synthetic LANCL2 modulators are being examined for potential benefit in models of inflammatory bowel disease [2-5].
General Comments
The LANCL2 protein has been shown to bind abscisic acid, an autocrine signalling molecule that is produced by human granulocytes, and by human and murine pancreatic β cells [8]. Cellular abscisic acid signals are mediated by a membrane-associated LANCL2/CD38 complex, and evidence exists that signalling is transmitted via a pertussis toxin-sensitive Gi protein.

References

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1. Bruzzone S, Moreschi I, Usai C, Guida L, Damonte G, Salis A, Scarfì S, Millo E, De Flora A, Zocchi E. (2007) Abscisic acid is an endogenous cytokine in human granulocytes with cyclic ADP-ribose as second messenger. Proc Natl Acad Sci USA, 104 (14): 5759-64. [PMID:17389374]

2. Carbo A, Gandour RD, Hontecillas R, Philipson N, Uren A, Bassaganya-Riera J. (2016) An N,N-Bis(benzimidazolylpicolinoyl)piperazine (BT-11): A Novel Lanthionine Synthetase C-Like 2-Based Therapeutic for Inflammatory Bowel Disease. J Med Chem, 59 (22): 10113-10126. [PMID:27933891]

3. Leber A, Hontecillas R, Zoccoli-Rodriguez V, Bassaganya-Riera J. (2018) Activation of LANCL2 by BT-11 Ameliorates IBD by Supporting Regulatory T Cell Stability Through Immunometabolic Mechanisms. Inflamm Bowel Dis, 24 (9): 1978-1991. [PMID:29718324]

4. Leber A, Hontecillas R, Zoccoli-Rodriguez V, Chauhan J, Bassaganya-Riera J. (2019) Oral Treatment with BT-11 Ameliorates Inflammatory Bowel Disease by Enhancing Regulatory T Cell Responses in the Gut. J Immunol, 202 (7): 2095-2104. [PMID:30760618]

5. Lu P, Hontecillas R, Horne WT, Carbo A, Viladomiu M, Pedragosa M, Bevan DR, Lewis SN, Bassaganya-Riera J. (2012) Computational modeling-based discovery of novel classes of anti-inflammatory drugs that target lanthionine synthetase C-like protein 2. PLoS ONE, 7 (4): e34643. [PMID:22509338]

6. Lu P, Hontecillas R, Philipson CW, Bassaganya-Riera J. (2014) Lanthionine synthetase component C-like protein 2: a new drug target for inflammatory diseases and diabetes. Curr Drug Targets, 15 (6): 565-72. [PMID:24628287]

7. Mayer H, Pongratz M, Prohaska R. (2001) Molecular cloning, characterization, and tissue-specific expression of human LANCL2, a novel member of the LanC-like protein family. DNA Seq, 12 (3): 161-6. [PMID:11762191]

8. Sturla L, Fresia C, Guida L, Bruzzone S, Scarfì S, Usai C, Fruscione F, Magnone M, Millo E, Basile G et al.. (2009) LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells. J Biol Chem, 284 (41): 28045-57. [PMID:19667068]

How to cite this page

Abscisic acid receptor complex: LanC like 2. Last modified on 23/04/2019. Accessed on 11/08/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3082.