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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | 238 | 16q23.1 | NUDT7 | nudix hydrolase 7 | |
| Mouse | - | 236 | 8 E1 | Nudt7 | nudix hydrolase 7 | |
| Rat | - | 236 | 19q12 | Nudt7 | nudix hydrolase 7 | |
| Gene and Protein Information Comments | ||||||
| Alternatively spliced transcript variants which encode multiple isoforms have been found for the human, rat and mouse genes. | ||||||
| Previous and Unofficial Names |
| nudix (nucleoside diphosphate linked moiety X)-type motif 7 |
| Database Links |
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| Alphafold | P0C024 (Hs), Q99P30 (Mm) |
| BRENDA | 3.6.1.- |
| Ensembl Gene | ENSG00000140876 (Hs), ENSMUSG00000031767 (Mm), ENSRNOG00000011976 (Rn) |
| Entrez Gene | 283927 (Hs), 67528 (Mm), 361413 (Rn) |
| Human Protein Atlas | ENSG00000140876 (Hs) |
| KEGG Enzyme | 3.6.1.- |
| KEGG Gene | hsa:283927 (Hs), mmu:67528 (Mm), rno:361413 (Rn) |
| OMIM | 609231 (Hs) |
| Pharos | P0C024 (Hs) |
| RefSeq Nucleotide | NM_001105663 (Hs), NM_024437 (Mm), NM_001305426 (Rn) |
| RefSeq Protein | NP_001099133 (Hs), NP_077757 (Mm), NP_001292355 (Rn) |
| UniProtKB | P0C024 (Hs), Q99P30 (Mm) |
| Wikipedia | NUDT7 (Hs) |
| Enzyme Reaction |
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Download all structure-activity data for this target as a CSV file 
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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| General Comments |
| Nudix hydrolase 7 (NUDT7) is one of a family of ~24 human genes that encode phosphohydrolase enzymes that share structural and functional properties. Nudix hydrolase activity is required for the removal of toxic nucleotide metabolites from cells, and for regulating the availability of important nucleotide substrates, cofactors (e.g. coenzyme A; CoA), and signalling molecules. The NUDT7 protein contains a CoA-binding motif and a C-terminal peroxisomal targeting signal and is expressed predominantly in the liver [1,3]. Through regulation of CoA, NUDT7 has been linked to metabolic and glucose homoeostasis and peroxisomal function [2]. Dysregulation of the NUDT7-PGAM1 axis has been implicated in pathologic cartilage-degradation in osteoarthritis [5]. |
1. Gasmi L, McLennan AG. (2001) The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives. Biochem J, 357 (Pt 1): 33-8. [PMID:11415433]
2. Jackowski S, Leonardi R. (2014) Deregulated coenzyme A, loss of metabolic flexibility and diabetes. Biochem Soc Trans, 42 (4): 1118-22. [PMID:25110012]
3. Reilly SJ, Tillander V, Ofman R, Alexson SE, Hunt MC. (2008) The nudix hydrolase 7 is an Acyl-CoA diphosphatase involved in regulating peroxisomal coenzyme A homeostasis. J Biochem, 144 (5): 655-63. [PMID:18799520]
4. Resnick E, Bradley A, Gan J, Douangamath A, Krojer T, Sethi R, Aimon A, Amitai G, Belini D, Bennett J, Fairhead M et al.. (2018) Rapid covalent-probe discovery by electrophile fragment screening. bioRxiv,. DOI: 10.1101/442806
5. Song J, Baek IJ, Chun CH, Jin EJ. (2018) Dysregulation of the NUDT7-PGAM1 axis is responsible for chondrocyte death during osteoarthritis pathogenesis. Nat Commun, 9 (1): 3427. [PMID:30143643]
