nudix hydrolase 7 | Hydrolases | IUPHAR/BPS Guide to PHARMACOLOGY

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nudix hydrolase 7

Target not currently curated in GtoImmuPdb

Target id: 3085

Nomenclature: nudix hydrolase 7

Family: Hydrolases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 238 16q23.1 NUDT7 nudix hydrolase 7
Mouse - 236 Chromosome 8, 60.53 cM; 8 E1 Nudt7 nudix (nucleoside diphosphate linked moiety X)-type motif 7
Rat - 236 19q12 Nudt7 nudix hydrolase 7
Gene and Protein Information Comments
Alternatively spliced transcript variants which encode multiple isoforms have been found for the human, rat and mouse genes.
Database Links
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.6.1.-

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Inhibitors
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Ligand Sp. Action Value Parameter Reference
NUDT7-COV-1 Hs Inhibition 6.0 pIC50 4
pIC50 6.0 (IC50 1.1x10-6 M) [4]
Description: In an enzymatic assay monitoring NUDT7-induced acetyl-CoA hydrolysis; 30 minutes pre-incubation with inhibitor.
General Comments
Nudix hydrolase 7 (NUDT7) is one of a family of ~24 human genes that encode phosphohydrolase enzymes that share structural and functional properties. Nudix hydrolase activity is required for the removal of toxic nucleotide metabolites from cells, and for regulating the availability of important nucleotide substrates, cofactors (e.g. coenzyme A; CoA), and signalling molecules. The NUDT7 protein contains a CoA-binding motif and a C-terminal peroxisomal targeting signal and is expressed predominantly in the liver [1,3]. Through regulation of CoA, NUDT7 has been linked to metabolic and glucose homoeostasis and peroxisomal function [2]. Dysregulation of the NUDT7-PGAM1 axis has been implicated in pathologic cartilage-degradation in osteoarthritis [5].

References

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1. Gasmi L, McLennan AG. (2001) The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives. Biochem. J., 357 (Pt 1): 33-8. [PMID:11415433]

2. Jackowski S, Leonardi R. (2014) Deregulated coenzyme A, loss of metabolic flexibility and diabetes. Biochem. Soc. Trans., 42 (4): 1118-22. [PMID:25110012]

3. Reilly SJ, Tillander V, Ofman R, Alexson SE, Hunt MC. (2008) The nudix hydrolase 7 is an Acyl-CoA diphosphatase involved in regulating peroxisomal coenzyme A homeostasis. J. Biochem., 144 (5): 655-63. [PMID:18799520]

4. Resnick E, Bradley A, Gan J, Douangamath A, Krojer T, Sethi R, Aimon A, Amitai G, Belini D, Bennett J, Fairhead M et al.. (2018) Rapid covalent-probe discovery by electrophile fragment screening. bioRxiv,. DOI: 10.1101/442806

5. Song J, Baek IJ, Chun CH, Jin EJ. (2018) Dysregulation of the NUDT7-PGAM1 axis is responsible for chondrocyte death during osteoarthritis pathogenesis. Nat Commun, 9 (1): 3427. [PMID:30143643]

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