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carbonic anhydrase 2

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Target not currently curated in GtoImmuPdb

Target id: 3092

Nomenclature: carbonic anhydrase 2

Abbreviated Name: CA II

Family: Carbonic anhydrases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 260 8q21.2 CA2 carbonic anhydrase 2
Mouse - 260 3 3.23 cM Car2 carbonic anhydrase 2
Rat - 260 2q23 Car2 carbonic anhydrase 2
Gene and Protein Information Comments
Two transcript variants encoding different isoforms have been identified for the human and mouse genes.
Previous and Unofficial Names Click here for help
CAII | Car2 | carbonic anhydrase II
Database Links Click here for help
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 4.2.1.1

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 5a [PMID: 31287314] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.0 pKi 1
pKi 7.0 (Ki 9.65x10-8 M) [1]
compound 5b [PMID: 31287314] Small molecule or natural product Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition 6.7 pKi 1
pKi 6.7 (Ki 2.154x10-7 M) [1]
Immuno Process Associations
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0045672 positive regulation of osteoclast differentiation IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 2 GO processes, IEA only
GO:0030316 osteoclast differentiation TAS
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GO:0045672 positive regulation of osteoclast differentiation IEA

References

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1. Berrino E, Milazzo L, Micheli L, Vullo D, Angeli A, Bozdag M, Nocentini A, Menicatti M, Bartolucci G, di Cesare Mannelli L et al.. (2019) Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis. J. Med. Chem., 62 (15): 7233-7249. [PMID:31287314]

How to cite this page

Carbonic anhydrases: carbonic anhydrase 2. Last modified on 24/07/2019. Accessed on 27/11/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3092.