Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	510	1q23.3	NECTIN4	nectin cell adhesion molecule 4

Previous and Unofficial Names

Ig superfamily receptor LNIR | Nectin-4 | Nectin cell adhesion molecule 4 | Poliovirus receptor-related protein 4 | PVRL4

Database Links
Alphafold	Q96NY8 (Hs)
ChEMBL Target	CHEMBL3712928 (Hs)
Ensembl Gene	ENSG00000143217 (Hs)
Entrez Gene	81607 (Hs)
Human Protein Atlas	ENSG00000143217 (Hs)
KEGG Gene	hsa:81607 (Hs)
OMIM	609607 (Hs)
Pharos	Q96NY8 (Hs)
RefSeq Nucleotide	NM_030916 (Hs)
RefSeq Protein	NP_112178 (Hs)
UniProtKB	Q96NY8 (Hs)
Wikipedia	NECTIN4 (Hs)

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Antibodies
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Antibody Sp. Action Value Parameter Reference enfortumab vedotin Hs Binding - - 3 ⤷ [3]

Other Binding Ligands
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Ligand Sp. Action Value Parameter Reference BT7480 Hs Binding 8.3 pKd 4 ⤷ pKd 8.3 (Kd 5.1x10-9 M) [4] Description: Binding affinity determined by SPR

Immunopharmacology Comments

Nectin 4 is the target of the immuno-oncology monoclonal antibody enfortumab vedotin, which was FDA approved in 2019 as a therapy for locally advanced/metastatic urothelial cancer that has been previously treated using a PD-1 or PD-L1 immune checkpoint inhibitor and platinum-containing chemotherapy in the neoadjuvant/adjuvant, locally advanced or metastatic setting.

Clinically-Relevant Mutations and Pathophysiology
Disease:  Ectodermal dysplasia-syndactyly syndrome Description: A rare autosomal recessive disorder that is characterised by sparse to absent scalp hair, eyebrows, and eyelashes, cutaneous syndactyly and teeth abnormalities. OMIM: 613573 Orphanet: ORPHA247820 Role:  Homozygous or compound heterozygous mutation in the NECTIN4 gene cause EDSS1. References:  1-2

General Comments
Nectin 4 is a surface protein that participates in Ca2+-independent cell-cell adhesion. It is a component of adherens junctions, through interaction with the adaptor protein afadin (AFDN), which links it to the actin cytoskeleton. Nectin 4 is highly expressed in a wide range of solid tumours. The metalloproteinase ADAM17/TACE can cleave nectin 4's extracellular domain to create a secreted form.