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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| SARS-CoV-2 | - | 121 | ORF7a | Protein 7a | ||
| SARS-CoV | - | 122 | ORF7a | Protein 7a | ||
| Previous and Unofficial Names |
| orf7a |
| Database Links |
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| Entrez Gene | 43740573 (SARS-CoV-2), 1489674 (SARS-CoV) |
| RefSeq Protein | YP_009825057 (SARS-CoV), YP_009724395 (SARS-CoV-2) |
| UniProtKB | P0DTC7 (SARS-CoV-2), P59635 (SARS-CoV) |
| Selected 3D Structures |
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| General Comments |
| The SARS-CoV protein 7a has no significant sequence homology with any other known viral or non-viral proteins. Sequence analysis predicts that ORF 7a encodes a type I transmembrane protein, and a crystal structure reveals that its luminal domain is topologically immunoglobulin-like [1]. SARS-CoV 7a is an accessory protein that is dispensible for virus replication. It's main function appears to be disruption of the host cell cycle and induction of caspase-dependent apoptosis [2]. Co-precipitation of 7a and host Ap4A-hydrolase reveals another interaction that may cause cell cycle arrest and apoptosis [3]. By homology SARS-CoV-2 protein 7a is likely to perform a similar function(s). |
1. Nelson CA, Pekosz A, Lee CA, Diamond MS, Fremont DH. (2005) Structure and intracellular targeting of the SARS-coronavirus Orf7a accessory protein. Structure, 13 (1): 75-85. [PMID:15642263]
2. Tan YJ, Fielding BC, Goh PY, Shen S, Tan TH, Lim SG, Hong W. (2004) Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase-dependent pathway. J Virol, 78 (24): 14043-7. [PMID:15564512]
3. Vasilenko N, Moshynskyy I, Zakhartchouk A. (2010) SARS coronavirus protein 7a interacts with human Ap4A-hydrolase. Virol J, 7: 31. [PMID:20144233]
