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CoV Protein 7a

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Target not currently curated in GtoImmuPdb

Target id: 3119

Nomenclature: CoV Protein 7a

Family: Coronavirus (CoV) proteins

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
SARS-CoV-2 - 121 ORF7a Protein 7a
SARS-CoV - 122 ORF7a Protein 7a
Previous and Unofficial Names Click here for help
orf7a
Database Links Click here for help
Entrez Gene
RefSeq Protein
UniProtKB
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  STRUCTURE OF THE SARS-CORONAVIRUS ORF7A ACCESSORY PROTEIN.
PDB Id:  1XAK
Resolution:  1.8Å
Species:  None
References:  1
General Comments
The SARS-CoV protein 7a has no significant sequence homology with any other known viral or non-viral proteins. Sequence analysis predicts that ORF 7a encodes a type I transmembrane protein, and a crystal structure reveals that its luminal domain is topologically immunoglobulin-like [1]. SARS-CoV 7a is an accessory protein that is dispensible for virus replication. It's main function appears to be disruption of the host cell cycle and induction of caspase-dependent apoptosis [2]. Co-precipitation of 7a and host Ap4A-hydrolase reveals another interaction that may cause cell cycle arrest and apoptosis [3]. By homology SARS-CoV-2 protein 7a is likely to perform a similar function(s).

References

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1. Nelson CA, Pekosz A, Lee CA, Diamond MS, Fremont DH. (2005) Structure and intracellular targeting of the SARS-coronavirus Orf7a accessory protein. Structure, 13 (1): 75-85. [PMID:15642263]

2. Tan YJ, Fielding BC, Goh PY, Shen S, Tan TH, Lim SG, Hong W. (2004) Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase-dependent pathway. J. Virol., 78 (24): 14043-7. [PMID:15564512]

3. Vasilenko N, Moshynskyy I, Zakhartchouk A. (2010) SARS coronavirus protein 7a interacts with human Ap4A-hydrolase. Virol. J., 7: 31. [PMID:20144233]

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