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stabilin 1

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 3247

Nomenclature: stabilin 1

Family: Scavenger receptors

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 2570 3p21.1 STAB1 stabilin 1
Mouse 1 2571 14 19.09 cM Stab1 stabilin 1
Rat - - 16p16 Stab1 stabilin 1
Previous and Unofficial Names Click here for help
CLEVER-1 | FEEL-1 | FEX1 | SCARH2 | STAB-1
Database Links Click here for help
Alphafold
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file go icon to follow link

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
bexmarilimab Peptide Immunopharmacology Ligand Hs Binding 9.1 pKd 1
pKd 9.1 (Kd 7.5x10-10 M) [1]
Description: Binding affinity determined by SPR
bexmarilimab Peptide Immunopharmacology Ligand Monkey Binding 9.0 pKd 1
pKd 9.0 (Kd 9.2x10-10 M) [1]
Description: Binding affinity determined by SPR
Immunopharmacology Comments
Stabilin-1/CLEVER-1 scavenges and clears unwanted self components, and promotes immunosuppression in the tumour microenvironment. Expression on macrophages and endothelial cells is induced during chronic inflammation. Blocking Stabilin-1 on monocytes or macrophages converts immunosuppressive M2 macrophages into immunostimulatory M1 macrophages, and this effect is being investigated as a mechanism to induce T cell-dependent killing of cancer cells [1-2].

References

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1. Hollmén M, Maksimow M, Rannikko JH, Karvonen MK, Vainio M, Jalkanen S, Jalkanen M, Mandelin J. (2022) Nonclinical Characterization of Bexmarilimab, a Clever-1-Targeting Antibody for Supporting Immune Defense Against Cancers. Mol Cancer Ther, 21 (7): 1207-1218. [PMID:35500016]

2. Viitala M, Virtakoivu R, Tadayon S, Rannikko J, Jalkanen S, Hollmén M. (2019) Immunotherapeutic Blockade of Macrophage Clever-1 Reactivates the CD8+ T-cell Response against Immunosuppressive Tumors. Clin Cancer Res, 25 (11): 3289-3303. [PMID:30755440]

How to cite this page

Scavenger receptors: stabilin 1. Last modified on 29/08/2023. Accessed on 27/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3247.