Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	2570	3p21.1	STAB1	stabilin 1
Mouse	1	2571	14 19.09 cM	Stab1	stabilin 1
Rat	-	-	16p16	Stab1	stabilin 1

Previous and Unofficial Names

CLEVER-1 | FEEL-1 | FEX1 | SCARH2 | STAB-1

Database Links
Alphafold	Q9NY15 (Hs)
Ensembl Gene	ENSG00000010327 (Hs), ENSMUSG00000042286 (Mm), ENSRNOG00000018434 (Rn)
Entrez Gene	23166 (Hs), 192187 (Mm), 100363145 (Rn)
Human Protein Atlas	ENSG00000010327 (Hs)
KEGG Gene	hsa:23166 (Hs), mmu:192187 (Mm), rno:100363145 (Rn)
OMIM	608560 (Hs)
Pharos	Q9NY15 (Hs)
UniProtKB	Q9NY15 (Hs)
Wikipedia	STAB1 (Hs)

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols		Click column headers to sort
Antibody Sp. Action Value Parameter Reference bexmarilimab Hs Binding 9.1 pKd 1 ⤷ pKd 9.1 (Kd 7.5x10-10 M) [1] Description: Binding affinity determined by SPR bexmarilimab Monkey Binding 9.0 pKd 1 ⤷ pKd 9.0 (Kd 9.2x10-10 M) [1] Description: Binding affinity determined by SPR

Immunopharmacology Comments

Stabilin-1/CLEVER-1 scavenges and clears unwanted self components, and promotes immunosuppression in the tumour microenvironment. Expression on macrophages and endothelial cells is induced during chronic inflammation. Blocking Stabilin-1 on monocytes or macrophages converts immunosuppressive M2 macrophages into immunostimulatory M1 macrophages, and this effect is being investigated as a mechanism to induce T cell-dependent killing of cancer cells [1-2].

Immuno Process Associations

Immuno Process:  Antigen presentation GO Annotations:  Associated to 3 GO processes GO:0005041 low-density lipoprotein particle receptor activity IDA GO:0005044 scavenger receptor activity IDA GO:0006898 receptor-mediated endocytosis TAS

Immuno Process:  Inflammation GO Annotations:  Associated to 1 GO processes, IEA only click arrow to show/hide IEA associations GO:0006954 inflammatory response IEA