Gene and Protein Information
class A G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	374	5q13.3	F2RL2	coagulation factor II thrombin receptor like 2
Mouse	7	369	13 50.38 cM	F2rl2	coagulation factor II thrombin receptor like 2
Rat	7	368	2q12	F2rl2	coagulation factor II (thrombin) receptor-like 2

Previous and Unofficial Names

coagulation factor II receptor-like 2 | protease-activated receptor 3 | thrombin receptor-like 2 | coagulation factor II (thrombin) receptor-like 2

Database Links
Specialist databases
GPCRdb	par3_human (Hs), par3_mouse (Mm), par3_rat (Rn)
Other databases
Alphafold	O00254 (Hs), O08675 (Mm), Q920E1 (Rn)
ChEMBL Target	CHEMBL5477 (Hs)
Ensembl Gene	ENSG00000164220 (Hs), ENSMUSG00000021675 (Mm), ENSRNOG00000018054 (Rn)
Entrez Gene	2151 (Hs), 14064 (Mm), 29636 (Rn)
Human Protein Atlas	ENSG00000164220 (Hs)
KEGG Gene	hsa:2151 (Hs), mmu:14064 (Mm), rno:29636 (Rn)
OMIM	601919 (Hs)
Pharos	O00254 (Hs)
RefSeq Nucleotide	NM_004101 (Hs), NM_010170 (Mm), NM_053313 (Rn)
RefSeq Protein	NP_004092 (Hs), NP_034300 (Mm), NP_445765 (Rn)
UniProtKB	O00254 (Hs), O08675 (Mm), Q920E1 (Rn)
Wikipedia	F2RL2 (Hs)

Natural/Endogenous Ligands
thrombin {Sp: Human} , thrombin {Sp: Mouse} , thrombin {Sp: Rat}

Agonist proteases (Human)

thrombin (F2, P00734)

Expression Datasets
Show »« Hide Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website] There should be a chart of expression data here, you may need to enable JavaScript!

Physiological Consequences of Altering Gene Expression
PAR3 is required for neuronal protective effects of activated protein C (APC). PAR3 knockout mice do not display neuronal protective effects of APC Species:  Mouse Tissue:  CNS Technique:  Gene knockouts References:  2
PAR3 knockout mice are protected against thrombosis. PAR3 knockout mice are protected against ferric chloride-induced thrombosis and thromboplastin-induced pulmonary embolism, with decreased platelet activation responses to thrombin. Species:  Mouse Tissue:  Platelets Technique:  Gene knockouts References:  1,3

Phenotypes, Alleles and Disease Models

Mouse data from MGI

Show »« Hide Allele Composition & genetic background Accession Phenotype Id Phenotype Reference F2rl2tm1Cgh F2rl2tm1Cgh/F2rl2tm1Cgh involves: 129S4/SvJae * C57BL/6 MGI:1298208  MP:0005464 abnormal platelet physiology PMID: 9716134  F2rl2tm1Cgh F2rl2tm1Cgh/F2rl2tm1Cgh involves: 129S4/SvJae * C57BL/6 MGI:1298208  MP:0005606 increased bleeding time PMID: 12384423  F2rl2tm1Cgh F2rl2tm1Cgh/F2rl2tm1Cgh involves: 129S4/SvJae * C57BL/6 MGI:1298208  MP:0005048 thrombosis PMID: 12384423