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TPC2

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Target not currently curated in GtoImmuPdb

Target id: 393

Nomenclature: TPC2

Family: CatSper and Two-Pore channels

Gene and Protein Information Click here for help
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 12 0 752 11q13.3 TPCN2 two pore segment channel 2
Mouse 12 0 731 7 F5 Tpcn2 two pore segment channel 2
Rat 6 0 711 1q42 Tpcn2 two pore segment channel 2
Previous and Unofficial Names Click here for help
two pore calcium channel protein 2
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Functional Characteristics Click here for help
Organelle voltage-independent Na+-selective channel (Na+>>K+>>Ca2+). Sensitive to the levels of PI(3,5)P2. Activated by decreases in [ATP] or depletion of extracellular amino acids

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Activators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference
phosphatidyl (3,5) inositol bisphosphate Small molecule or natural product Click here for species-specific activity table Hs Activation 6.4 pEC50 - - 1
pEC50 6.4 (EC50 4x10-7 M) [1]
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference
verapamil Small molecule or natural product Approved drug Click here for species-specific activity table Hs Inhibition 5.0 pIC50 - - 1
pIC50 5.0 (IC50 1x10-5 M) [1]
Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Tpcn2Gt(YHD437)Byg Tpcn2Gt(YHD437)Byg/Tpcn2Gt(YHD437)Byg
involves: 129P2/OlaHsd * C57BL/6
MGI:2385297  MP:0003562 abnormal pancreatic beta cell physiology PMID: 19387438 

References

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1. Wang X, Zhang X, Dong XP, Samie M, Li X, Cheng X, Goschka A, Shen D, Zhou Y, Harlow J et al.. (2012) TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell, 151 (2): 372-83. [PMID:23063126]

Contributors

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