Gene and Protein Information
Species	TM	P Loops	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	12	0	752	11q13.3	TPCN2	two pore segment channel 2
Mouse	12	0	731	7 F5	Tpcn2	two pore segment channel 2
Rat	6	0	711	1q42	Tpcn2	two pore segment channel 2

Previous and Unofficial Names

two pore calcium channel protein 2

Database Links
Alphafold	Q8NHX9 (Hs), Q8BWC0 (Mm)
Ensembl Gene	ENSG00000162341 (Hs), ENSMUSG00000048677 (Mm), ENSRNOG00000013387 (Rn)
Entrez Gene	219931 (Hs), 233979 (Mm), 309139 (Rn)
Human Protein Atlas	ENSG00000162341 (Hs)
KEGG Gene	hsa:219931 (Hs), mmu:233979 (Mm), rno:309139 (Rn)
OMIM	612163 (Hs)
Pharos	Q8NHX9 (Hs)
RefSeq Nucleotide	NM_139075 (Hs), NM_146206 (Mm), NM_001107566 (Rn)
RefSeq Protein	NP_620714 (Hs), NP_666318 (Mm), NP_001101036 (Rn)
UniProtKB	Q8NHX9 (Hs), Q8BWC0 (Mm)
Wikipedia	TPCN2 (Hs)

Functional Characteristics
Organelle voltage-independent Na+-selective channel (Na+>>K+>>Ca2+). Sensitive to the levels of PI(3,5)P2. Activated by decreases in [ATP] or depletion of extracellular amino acids

Download all structure-activity data for this target as a CSV file

Activators
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference phosphatidyl (3,5) inositol bisphosphate Hs Activation 6.4 pEC50 - - 4 ⤷ pEC50 6.4 (EC50 4x10-7 M) [4] TPC2-A1-N Hs Activation 5.1 pEC50 - - 1 ⤷ pEC50 5.1 (EC50 7.8x10-6 M) [1] Description: In cells stably expressing hTPC2L11A/L12A using a FLIPR-based Ca2+ assay TPC2-A1-P Hs Activation 5.0 pEC50 - - 1 ⤷ pEC50 5.0 (EC50 1.05x10-5 M) [1] Description: In cells stably expressing hTPC2L11A/L12A using a FLIPR-based Ca2+ assay

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference SG-005 Hs Inhibition 5.6 pIC50 - - 2 ⤷ pIC50 5.6 (IC50 2.5x10-6 M) [2] Description: Inhibition of TPC2-A1-N-mediated activation of hTPC2. MT-8 Hs Inhibition 5.6 pIC50 - - 3 ⤷ pIC50 5.6 (IC50 2.6x10-6 M) [3] Description: Inhibition of hTPC2 stably overexpressed in HEK293 cells, in endolysosomal patch clamp experiments SG-094 Hs Inhibition 5.1 pIC50 - - 2 ⤷ pIC50 5.1 (IC50 8.3x10-6 M) [2] Description: Inhibition of TPC2-A1-P-mediated activation of hTPC2. UM-9 Hs Inhibition 5.0 pIC50 - - 3 ⤷ pIC50 5.0 (IC50 9.5x10-6 M) [3] Description: Inhibition of hTPC2 stably overexpressed in HEK293 cells, in endolysosomal patch clamp experiments

Channel Blockers
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference verapamil Hs Inhibition 5.0 pIC50 - - 4 ⤷ pIC50 5.0 (IC50 1x10-5 M) [4]

Phenotypes, Alleles and Disease Models	Mouse data from MGI
Show »« Hide Allele Composition & genetic background Accession Phenotype Id Phenotype Reference Tpcn2Gt(YHD437)Byg Tpcn2Gt(YHD437)Byg/Tpcn2Gt(YHD437)Byg involves: 129P2/OlaHsd * C57BL/6 MGI:2385297  MP:0003562 abnormal pancreatic beta cell physiology PMID: 19387438