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Target not currently curated in GtoImmuPdb
Target id: 412
Nomenclature: GABAA receptor β3 subunit
Family: GABAA receptors
Annotation status:
Annotated and expert reviewed. Please contact us if you can help with updates.
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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 4 | 473 | 15q11.2-q12 | GABRB3 | gamma-aminobutyric acid type A receptor beta3 subunit | 6-7 |
Mouse | 4 | 473 | 7 C | Gabrb3 | gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 | 2 |
Rat | 4 | 473 | 1q22 | Gabrb3 | gamma-aminobutyric acid type A receptor beta 3 subunit | 4,8 |
Database Links ![]() |
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CATH/Gene3D | 2.70.170.10 |
ChEMBL Target | CHEMBL1847 (Hs), CHEMBL2094133 (Mm), CHEMBL1907607 (Rn) |
DrugBank Target | P28472 (Hs), P28472 (Hs) |
Ensembl Gene | ENSG00000166206 (Hs), ENSMUSG00000033676 (Mm), ENSRNOG00000014938 (Rn) |
Entrez Gene | 2562 (Hs), 14402 (Mm), 24922 (Rn) |
Human Protein Atlas | ENSG00000166206 (Hs) |
KEGG Gene | hsa:2562 (Hs), mmu:14402 (Mm), rno:24922 (Rn) |
OMIM | 137192 (Hs) |
Orphanet | ORPHA159621 (Hs) |
RefSeq Nucleotide | NM_000814 (Hs), NM_021912 (Hs), NM_008071 (Mm), NM_017065 (Rn) |
RefSeq Protein | NP_000805 (Hs), NP_068712 (Hs), NP_032097 (Mm), NP_058761 (Rn) |
UniProtKB | P28472 (Hs), P63080 (Mm), P63079 (Rn) |
Wikipedia | GABRB3 (Hs) |
Selected 3D Structures ![]() |
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Natural/Endogenous Ligands ![]() |
GABA |
Download all structure-activity data for this target as a CSV file
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Allosteric Modulators | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||
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Tissue Distribution ![]() |
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Clinically-Relevant Mutations and Pathophysiology ![]() |
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Biologically Significant Variants ![]() |
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1. Buhr A, Bianchi MT, Baur R, Courtet P, Pignay V, Boulenger JP, Gallati S, Hinkle DJ, Macdonald RL, Sigel E. (2002) Functional characterization of the new human GABA(A) receptor mutation beta3(R192H). Hum. Genet., 111 (2): 154-60. [PMID:12189488]
2. Ferguson C, Hardy SL, Werner DF, Hileman SM, Delorey TM, Homanics GE. (2007) New insight into the role of the beta3 subunit of the GABAA-R in development, behavior, body weight regulation, and anesthesia revealed by conditional gene knockout. BMC Neurosci, 8: 85. [PMID:17927825]
3. Kirkness EF, Fraser CM. (1993) A strong promoter element is located between alternative exons of a gene encoding the human gamma-aminobutyric acid-type A receptor beta 3 subunit (GABRB3). J. Biol. Chem., 268 (6): 4420-8. [PMID:8382702]
4. Lolait SJ, O'Carroll AM, Kusano K, Muller JM, Brownstein MJ, Mahan LC. (1989) Cloning and expression of a novel rat GABAA receptor. FEBS Lett., 246 (1-2): 145-8. [PMID:2540033]
5. Miller PS, Aricescu AR. (2014) Crystal structure of a human GABAA receptor. Nature, 512 (7514): 270-5. [PMID:24909990]
6. Wagstaff J, Chaillet JR, Lalande M. (1991) The GABAA receptor beta 3 subunit gene: characterization of a human cDNA from chromosome 15q11q13 and mapping to a region of conserved synteny on mouse chromosome 7. Genomics, 11 (4): 1071-8. [PMID:1664410]
7. Wagstaff J, Knoll JH, Fleming J, Kirkness EF, Martin-Gallardo A, Greenberg F, Graham JM, Menninger J, Ward D, Venter JC. (1991) Localization of the gene encoding the GABAA receptor beta 3 subunit to the Angelman/Prader-Willi region of human chromosome 15. Am. J. Hum. Genet., 49 (2): 330-7. [PMID:1714232]
8. Ymer S, Schofield PR, Draguhn A, Werner P, Köhler M, Seeburg PH. (1989) GABAA receptor beta subunit heterogeneity: functional expression of cloned cDNAs. EMBO J., 8 (6): 1665-70. [PMID:2548852]
9. Zezula J, Slany A, Sieghart W. (1996) Interaction of allosteric ligands with GABAA receptors containing one, two, or three different subunits. Eur. J. Pharmacol., 301 (1-3): 207-14. [PMID:8773466]