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| Quaternary Structure: Complexes |
| CGRP receptor |
| AM1 receptor |
| AM2 receptor |
Gene and Protein Information  |
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| class B G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 461 | 2q32.1 | CALCRL | calcitonin receptor like receptor | |
| Mouse | 7 | 463 | 2 D | Calcrl | calcitonin receptor-like | |
| Rat | 7 | 464 | 3q24 | Calcrl | calcitonin receptor like receptor | |
| Previous and Unofficial Names |
| CLR (unofficial abbreviation in common use) | CRLR |
| Database Links |
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| Specialist databases | |
| GPCRdb | calrl_human (Hs), calrl_mouse (Mm), calrl_rat (Rn) |
| Other databases | |
| Alphafold | Q16602 (Hs), Q9R1W5 (Mm), Q63118 (Rn) |
| CATH/Gene3D | 4.10.1240.10 |
| ChEMBL Target | CHEMBL3798 (Hs), CHEMBL2034811 (Mm), CHEMBL4755 (Rn) |
| Ensembl Gene | ENSG00000064989 (Hs), ENSMUSG00000059588 (Mm), ENSRNOG00000054695 (Rn) |
| Entrez Gene | 10203 (Hs), 54598 (Mm), 25029 (Rn) |
| Human Protein Atlas | ENSG00000064989 (Hs) |
| KEGG Gene | hsa:10203 (Hs), mmu:54598 (Mm), rno:25029 (Rn) |
| OMIM | 114190 (Hs) |
| Pharos | Q16602 (Hs) |
| RefSeq Nucleotide | NM_005795 (Hs), NM_018782 (Mm), NM_012717 (Rn) |
| RefSeq Protein | NP_005786 (Hs), NP_061252 (Mm), NP_036849 (Rn) |
| UniProtKB | Q16602 (Hs), Q9R1W5 (Mm), Q63118 (Rn) |
| Wikipedia | CALCRL (Hs) |
| Selected 3D Structures |
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| Natural/Endogenous Ligands |
| adrenomedullin, CGRP |
| Comments: Functional receptor is a dimer of 7TM and RAMP; ligand depends on RAMP |
| Immuno Process Associations | ||
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| Expression Datasets |
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| Phenotypes, Alleles and Disease Models
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Mouse data from MGI | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| General Comments |
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The product of the CALCRL gene, the calcitonin receptor-like receptor alone does not create a functional receptor. Coexpression with receptor activity modifying proteins (RAMPs) allows receptor signal transduction to occur. Reviewed in [2]. Calcitonin receptor-like receptor and RAMP1 make up the CGRP receptor. Calcitonin receptor-like receptor and RAMP2 make up the AM1 receptor. Calcitonin receptor-like receptor and RAMP3 make up the AM2 receptor. The most commonly used abbreviation for this receptor is CLR [2]. At the most recent of the international meetings on CGRP, calcitonin, amylin and adrenomedullin (8th International meeting, Switzerland, 2014), the participants agreed that this should continue to be the preferred abbreviation. The presence of CLR mRNA does not explain the phenotype of the receptor that is expressed. The expression of RAMP accessory proteins must also be considered. |
1. Kusano S, Kukimoto-Niino M, Akasaka R, Toyama M, Terada T, Shirouzu M, Shindo T, Yokoyama S. (2008) Crystal structure of the human receptor activity-modifying protein 1 extracellular domain. Protein Sci, 17 (11): 1907-14. [PMID:18725456]
2. Poyner DR, Sexton PM, Marshall I, Smith DM, Quirion R, Born W, Muff R, Fischer JA, Foord SM. (2002) International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol Rev, 54 (2): 233-46. [PMID:12037140]
3. ter Haar E, Koth CM, Abdul-Manan N, Swenson L, Coll JT, Lippke JA, Lepre CA, Garcia-Guzman M, Moore JM. (2010) Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism. Structure, 18 (9): 1083-93. [PMID:20826335]
