TRPP3 | Transient Receptor Potential channels | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 506

Nomenclature: TRPP3

Family: Transient Receptor Potential channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 613 5q31 PKD2L2 polycystin 2 like 2, transient receptor potential cation channel 3
Mouse 6 1 621 18 C Pkd2l2 polycystic kidney disease 2-like 2 1
Rat 6 1 621 18p12 Pkd2l2 polycystin 2 like 2
Previous and Unofficial Names
TRPP5 | polycystin 2 like 2 | polycystin 2 like 2, transient receptor potential cation channel
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Functional Characteristics
The functional characteristics of PKD2L2(PC2L2) has not been established yet.
Tissue Distribution
Species:  Human
Technique:  Northern Blot
References:  3
Widely expressed in fetal tissues (tissue-specific expression of splice variants).
Species:  Human
Technique:  RT-PCR
References:  1
Testis, heart
Species:  Mouse
Technique:  Northern Blot
References:  1
Functional Assays
Patch clamp (inside-out configuration)
Species:  Human
Tissue:  HEK 293 overexpressing TRPP3
Response measured:  Single channel current. This has not, however, been definitively identified as due to TRPP3.
References:  2
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Pkd2l2tm1Dgen Pkd2l2tm1Dgen/Pkd2l2tm1Dgen
involves: 129P2/OlaHsd * C57BL/6
MGI:1858231  MP:0001399 hyperactivity
General Comments
No known association with human polycystic kidney disease.


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1. Guo L, Schreiber TH, Weremowicz S, Morton CC, Lee C, Zhou J. (2000) Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization. Genomics, 64 (3): 241-51. [PMID:10756092]

2. Sutton KA, Jungnickel MK, Ward CJ, Harris PC, Florman HM. (2006) Functional characterization of PKDREJ, a male germ cell-restricted polycystin. J. Cell. Physiol., 209 (2): 493-500. [PMID:16883570]

3. Veldhuisen B, Spruit L, Dauwerse HG, Breuning MH, Peters DJ. (1999) Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2). Eur. J. Hum. Genet., 7 (8): 860-72. [PMID:10602361]


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