Target id: 52

Nomenclature: RAMP2

Quaternary Structure: Complexes
AMY2 receptor
AM1 receptor
Gene and Protein Information
Receptor activity modifying protein
Species TM AA Chromosomal Location Gene Symbol Gene Name References
Human 1 175 17q12-q21.1 RAMP2 receptor activity modifying protein 2 1,3
Mouse 1 189 11 D Ramp2 receptor (calcitonin) activity modifying protein 2 1
Rat 1 182 10q32.1 Ramp2 receptor activity modifying protein 2
Previous and Unofficial Names
receptor activity modifying protein 2
receptor (G protein-coupled) activity modifying protein 2
Database Links
Alphafold O60895 (Hs), Q9WUP0 (Mm), Q9JHJ1 (Rn)
ChEMBL Target CHEMBL2109232 (Hs), CHEMBL2364173 (Hs)
DrugBank Target O60895 (Hs)
Ensembl Gene ENSG00000131477 (Hs), ENSMUSG00000001240 (Mm), ENSRNOG00000020441 (Rn)
Entrez Gene 10266 (Hs), 54409 (Mm), 58966 (Rn)
Human Protein Atlas ENSG00000131477 (Hs)
KEGG Gene hsa:10266 (Hs), mmu:54409 (Mm), rno:58966 (Rn)
OMIM 605154 (Hs)
Pharos O60895 (Hs)
RefSeq Nucleotide NM_005854 (Hs), NM_019444 (Mm), NM_031646 (Rn)
RefSeq Protein NP_005845 (Hs), NP_062317 (Mm), NP_113834 (Rn)
UniProtKB O60895 (Hs), Q9WUP0 (Mm), Q9JHJ1 (Rn)
Wikipedia RAMP2 (Hs)
Protein Comments
In situ hybridisation studies of the rat brain have showed RAMP2 mRNA to be located predominantly in the hypothalamus and amygdala [4].

Immunochemistry shows RAMP2 to be present in the human middle meningeal, middle cerebral, pial and superficial temporal arteries [5].

Northern blotting shows mouse RAMP2 mRNA to be located predominantly in the brain, lung, heart and skeletal muscle [2].


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1. Derst C, Engel H, Grzeschik K, Daut J. (2000) Genomic structure and chromosome mapping of human and mouse RAMP genes. Cytogenet Cell Genet, 90 (1-2): 115-8. [PMID:11060459]

2. Husmann K, Sexton PM, Fischer JA, Born W. (2000) Mouse receptor-activity-modifying proteins 1, -2 and -3: amino acid sequence, expression and function. Mol Cell Endocrinol, 162 (1-2): 35-43. [PMID:10854696]

3. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM. (1998) RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature, 393 (6683): 333-9. [PMID:9620797]

4. Oliver KR, Kane SA, Salvatore CA, Mallee JJ, Kinsey AM, Koblan KS, Keyvan-Fouladi N, Heavens RP, Wainwright A, Jacobson M et al.. (2001) Cloning, characterization and central nervous system distribution of receptor activity modifying proteins in the rat. Eur J Neurosci, 14 (4): 618-28. [PMID:11556887]

5. Oliver KR, Wainwright A, Edvinsson L, Pickard JD, Hill RG. (2002) Immunohistochemical localization of calcitonin receptor-like receptor and receptor activity-modifying proteins in the human cerebral vasculature. J Cereb Blood Flow Metab, 22 (5): 620-9. [PMID:11973435]

How to cite this page

RAMP2. Last modified on 27/04/2006. Accessed on 18/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=52.