Contents:
| Quaternary Structure: Complexes |
| AMY2 receptor |
| AM1 receptor |
Gene and Protein Information  |
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| Receptor activity modifying protein | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | References |
| Human | 1 | 175 | 17q12-q21.1 | RAMP2 | receptor activity modifying protein 2 | 1,3 |
| Mouse | 1 | 189 | 11 D | Ramp2 | receptor (calcitonin) activity modifying protein 2 | 1 |
| Rat | 1 | 182 | 10q32.1 | Ramp2 | receptor activity modifying protein 2 | |
| Previous and Unofficial Names |
| receptor activity modifying protein 2 |
| receptor (G protein-coupled) activity modifying protein 2 |
| Database Links |
|
| Alphafold | O60895 (Hs), Q9WUP0 (Mm), Q9JHJ1 (Rn) |
| ChEMBL Target | CHEMBL2109232 (Hs), CHEMBL2364173 (Hs) |
| DrugBank Target | O60895 (Hs) |
| Ensembl Gene | ENSG00000131477 (Hs), ENSMUSG00000001240 (Mm), ENSRNOG00000020441 (Rn) |
| Entrez Gene | 10266 (Hs), 54409 (Mm), 58966 (Rn) |
| Human Protein Atlas | ENSG00000131477 (Hs) |
| KEGG Gene | hsa:10266 (Hs), mmu:54409 (Mm), rno:58966 (Rn) |
| OMIM | 605154 (Hs) |
| Pharos | O60895 (Hs) |
| RefSeq Nucleotide | NM_005854 (Hs), NM_019444 (Mm), NM_031646 (Rn) |
| RefSeq Protein | NP_005845 (Hs), NP_062317 (Mm), NP_113834 (Rn) |
| UniProtKB | O60895 (Hs), Q9WUP0 (Mm), Q9JHJ1 (Rn) |
| Wikipedia | RAMP2 (Hs) |
| Protein Comments |
|
In situ hybridisation studies of the rat brain have showed RAMP2 mRNA to be located predominantly in the hypothalamus and amygdala [4]. Immunochemistry shows RAMP2 to be present in the human middle meningeal, middle cerebral, pial and superficial temporal arteries [5]. Northern blotting shows mouse RAMP2 mRNA to be located predominantly in the brain, lung, heart and skeletal muscle [2]. |
References
1. Derst C, Engel H, Grzeschik K, Daut J. (2000) Genomic structure and chromosome mapping of human and mouse RAMP genes. Cytogenet Cell Genet, 90 (1-2): 115-8. [PMID:11060459]
2. Husmann K, Sexton PM, Fischer JA, Born W. (2000) Mouse receptor-activity-modifying proteins 1, -2 and -3: amino acid sequence, expression and function. Mol Cell Endocrinol, 162 (1-2): 35-43. [PMID:10854696]
3. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM. (1998) RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature, 393 (6683): 333-9. [PMID:9620797]
4. Oliver KR, Kane SA, Salvatore CA, Mallee JJ, Kinsey AM, Koblan KS, Keyvan-Fouladi N, Heavens RP, Wainwright A, Jacobson M et al.. (2001) Cloning, characterization and central nervous system distribution of receptor activity modifying proteins in the rat. Eur J Neurosci, 14 (4): 618-28. [PMID:11556887]
5. Oliver KR, Wainwright A, Edvinsson L, Pickard JD, Hill RG. (2002) Immunohistochemical localization of calcitonin receptor-like receptor and receptor activity-modifying proteins in the human cerebral vasculature. J Cereb Blood Flow Metab, 22 (5): 620-9. [PMID:11973435]
How to cite this page
RAMP2. Last modified on 27/04/2006. Accessed on 24/01/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=52.
