RAMP3

Target id: 53

Nomenclature: RAMP3

Quaternary Structure: Complexes
AMY3 receptor
AM2 receptor
Gene and Protein Information
Receptor activity modifying protein
Species TM AA Chromosomal Location Gene Symbol Gene Name References
Human 1 148 7p13-p12 RAMP3 receptor activity modifying protein 3 1,3
Mouse 1 147 11 A1 Ramp3 receptor (calcitonin) activity modifying protein 3 1
Rat 1 147 14q21 Ramp3 receptor activity modifying protein 3
Previous and Unofficial Names
receptor activity modifying protein 3
receptor (G protein-coupled) activity modifying protein 3
Database Links
ChEMBL Target CHEMBL2111191 (Hs), CHEMBL2111190 (Hs)
DrugBank Target O60896 (Hs)
Ensembl Gene ENSG00000122679 (Hs), ENSMUSG00000041046 (Mm), ENSRNOG00000008154 (Rn)
Entrez Gene 10268 (Hs), 56089 (Mm), 56820 (Rn)
Human Protein Atlas ENSG00000122679 (Hs)
KEGG Gene hsa:10268 (Hs), mmu:56089 (Mm), rno:56820 (Rn)
OMIM 605155 (Hs)
Pharos O60896 (Hs)
RefSeq Nucleotide NM_005856 (Hs), NM_019511 (Mm), NM_020100 (Rn)
RefSeq Protein NP_005847 (Hs), NP_062384 (Mm), NP_064485 (Rn)
UniProtKB O60896 (Hs), Q9WUP1 (Mm), Q9JJ73 (Rn)
Wikipedia RAMP3 (Hs)
Protein Comments
In situ hybridisation studies of the rat brain show RAMP3 mRNA to be located predominantly in the thalamus [4].

Immunochemistry shows RAMP3 to be present in the human middle meningeal, middle cerebral, pial and superficial temporal arteries [5].

Northern blotting shows mouse RAMP3 mRNA to be located predominantly in the brain, as well as weaker expression in the heart and kidney [2].

References

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1. Derst C, Engel H, Grzeschik K, Daut J. (2000) Genomic structure and chromosome mapping of human and mouse RAMP genes. Cytogenet. Cell Genet., 90 (1-2): 115-8. [PMID:11060459]

2. Husmann K, Sexton PM, Fischer JA, Born W. (2000) Mouse receptor-activity-modifying proteins 1, -2 and -3: amino acid sequence, expression and function. Mol. Cell. Endocrinol., 162 (1-2): 35-43. [PMID:10854696]

3. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM. (1998) RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature, 393 (6683): 333-9. [PMID:9620797]

4. Oliver KR, Kane SA, Salvatore CA, Mallee JJ, Kinsey AM, Koblan KS, Keyvan-Fouladi N, Heavens RP, Wainwright A, Jacobson M et al.. (2001) Cloning, characterization and central nervous system distribution of receptor activity modifying proteins in the rat. Eur. J. Neurosci., 14 (4): 618-28. [PMID:11556887]

5. Oliver KR, Wainwright A, Edvinsson L, Pickard JD, Hill RG. (2002) Immunohistochemical localization of calcitonin receptor-like receptor and receptor activity-modifying proteins in the human cerebral vasculature. J. Cereb. Blood Flow Metab., 22 (5): 620-9. [PMID:11973435]

How to cite this page

RAMP3. Last modified on 27/04/2006. Accessed on 01/12/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=53.