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Gene and Protein Information | |||||||
Species | TM | P Loops | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 24 | 0 | 2313 | 1q25.3 | CACNA1E | calcium voltage-gated channel subunit alpha1 E | |
Mouse | 24 | 0 | 2272 | 1 66.14 cM | Cacna1e | calcium channel, voltage-dependent, R type, alpha 1E subunit | |
Rat | 24 | 0 | 2222 | 13q21 | Cacna1e | calcium voltage-gated channel subunit alpha1 E |
Database Links | |
Alphafold | Q15878 (Hs), Q61290 (Mm), Q07652 (Rn) |
ChEMBL Target | CHEMBL1687682 (Hs) |
Ensembl Gene | ENSG00000198216 (Hs), ENSMUSG00000004110 (Mm), ENSRNOG00000002863 (Rn) |
Entrez Gene | 777 (Hs), 12290 (Mm), 54234 (Rn) |
Human Protein Atlas | ENSG00000198216 (Hs) |
KEGG Gene | hsa:777 (Hs), mmu:12290 (Mm), rno:54234 (Rn) |
OMIM | 601013 (Hs) |
Pharos | Q15878 (Hs) |
RefSeq Nucleotide | NM_000721 (Hs), NM_009782 (Mm), NM_019294 (Rn) |
RefSeq Protein | NP_000712 (Hs), NP_033912 (Mm), NP_062167 (Rn) |
UniProtKB | Q15878 (Hs), Q61290 (Mm), Q07652 (Rn) |
Wikipedia | CACNA1E (Hs) |
Associated Proteins | ||||||||||||||||||||||
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Functional Characteristics | |
R-type calcium current: Moderate voltage-activated, fast voltage-dependent inactivation |
Ion Selectivity and Conductance | ||||||
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Voltage Dependence | ||||||||||||||||
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Voltage Dependence Comments | ||||||||||||||||
Coexpression of Cav2.3 with β1, β3 or β4 subunits shifts the voltage-dependence of activation and inactivation further in the hyperpolarised direction [32,42]. Activation and inactivation time courses depend upon the nature of the β subunit, being slower with β2 [32]. |
Download all structure-activity data for this target as a CSV file
Gating inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gating Inhibitor Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Ni2+ blockade is detected as both a reduction in the maximum slope conductance and a shift in the current-voltage relation [60]. SNX482 has also been shown to block native IA potassium currents and cloned Kv4.3 currents at lower concentrations than that required for blockade of Cav2.3 currents [15]. |
Channel Blockers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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View species-specific channel blocker tables |
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Physiological Consequences of Altering Gene Expression | ||||||||||
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Phenotypes, Alleles and Disease Models | Mouse data from MGI | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Clinically-Relevant Mutations and Pathophysiology | ||||||||||||||||
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