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Farnesoid X receptor-β

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Target not currently curated in GtoImmuPdb

Target id: 604

Nomenclature: Farnesoid X receptor-β

Systematic Nomenclature: NR1H5

Family: 1H. Liver X receptor-like receptors

Gene and Protein Information Click here for help
Species AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1p13.2 NR1H5P nuclear receptor subfamily 1 group H member 5, pseudogene
Mouse 505 3 F2.2 Nr1h5 nuclear receptor subfamily 1, group H, member 5 1
Rat - 2q34 Nr1h5 nuclear receptor subfamily 1, group H, member 5
Gene and Protein Information Comments
FXRb is a pseudogene in human[1]
Previous and Unofficial Names Click here for help
FXRβ | Lanosterol receptor | Nr1h5p | nuclear receptor subfamily 1, group H, member 5, pseudogene | nuclear receptor subfamily 1
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
Wikipedia
Natural/Endogenous Ligands Click here for help
cholesten
desmosterol
lanosterol
vitamin D3
Comments: A series of oxysterols and bile acids are natural ligands

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Agonists Click here for help
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
lanosterol Small molecule or natural product Ligand is endogenous in the given species Ligand has a PDB structure Mm Agonist 6.0 pEC50 1
pEC50 6.0 [1]
vitamin D3 Small molecule or natural product Approved drug Ligand is endogenous in the given species Mm Agonist 5.0 pEC50 1
pEC50 5.0 [1]
desmosterol Small molecule or natural product Ligand is endogenous in the given species Mm Agonist 5.0 pEC50 1
pEC50 5.0 [1]
cholesten Small molecule or natural product Ligand is endogenous in the given species Mm Agonist 5.0 pEC50 1
pEC50 5.0 [1]
DNA Binding Click here for help
Structure:  Heterodimer
HRE core sequence:  AGTTCA N TGAACT
Response element: 
DNA Binding Comments
Also binds as RXR heterodimer to an everted repeat with a spacer of 2 (ER2).
Main Co-regulators Click here for help
Name Activity Specific Ligand dependent AF-2 dependent Comments References
NCOA1 Co-activator No Yes No 1
Tissue Distribution Click here for help
Ubiquitous
Species:  Mouse
Technique:  RT-PCR
References:  1
Biologically Significant Variants Click here for help
Type:  Splice variant
Species:  Mouse
Description:  nuclear receptor subfamily 1, group H, member 5 isoform 1
Amino acids:  505
Protein accession: 
References:  1
Type:  Splice variant
Species:  Mouse
Description:  nuclear receptor subfamily 1, group H, member 5 isoform 2
Amino acids:  497
Protein accession: 
References:  1
Type:  Splice variant
Species:  Mouse
Description:  nuclear receptor subfamily 1, group H, member 5 isoform 5
Amino acids:  447
Protein accession: 
References:  1

References

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1. Otte K, Kranz H, Kober I, Thompson P, Hoefer M, Haubold B, Remmel B, Voss H, Kaiser C, Albers M, Cheruvallath Z, Jackson D, Casari G, Koegl M, Pääbo S, Mous J, Kremoser C, Deuschle U. (2003) Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol. Mol. Cell. Biol., 23 (3): 864-72. [PMID:12529392]

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