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Target not currently curated in GtoImmuPdb
Target id: 623
Nomenclature: Estrogen-related receptor-β
Systematic Nomenclature: NR3B2
Family: 3B. Estrogen-related receptors
Gene and Protein Information  |
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| Species | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 433 | 14q24.3 | ESRRB | estrogen related receptor beta | 1 |
| Mouse | 433 | 12 40.49 cM | Esrrb | estrogen related receptor, beta | 5 |
| Rat | 433 | 6q31 | Esrrb | estrogen-related receptor beta | 5 |
| Previous and Unofficial Names |
| ERRβ | ESRL2 | estrogen receptor-like 2 | estrogen-related receptor β | DFNB35 | deafness, autosomal recessive 35 | nuclear receptor subfamily 3 group B member 2 | steroid hormone receptor ERR2 | estrogen-related receptor beta | estrogen related receptor, beta | estrogen related receptor |
| Database Links |
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| Alphafold | O95718 (Hs), Q61539 (Mm), P11475 (Rn) |
| CATH/Gene3D | 3.30.50.10 |
| ChEMBL Target | CHEMBL3751 (Hs) |
| Ensembl Gene | ENSG00000119715 (Hs), ENSMUSG00000021255 (Mm), ENSRNOG00000010259 (Rn) |
| Entrez Gene | 2103 (Hs), 26380 (Mm), 299210 (Rn) |
| Human Protein Atlas | ENSG00000119715 (Hs) |
| KEGG Gene | hsa:2103 (Hs), mmu:26380 (Mm), rno:299210 (Rn) |
| OMIM | 602167 (Hs) |
| Orphanet | ORPHA160244 (Hs) |
| Pharos | O95718 (Hs) |
| RefSeq Nucleotide | NM_004452 (Hs), NM_011934 (Mm), NM_001159500 (Mm), NM_001008516 (Rn) |
| RefSeq Protein | NP_004443 (Hs), NP_036064 (Mm), NP_001008516 (Rn) |
| UniProtKB | O95718 (Hs), Q61539 (Mm), P11475 (Rn) |
| Wikipedia | ESRRB (Hs) |
| Natural/Endogenous Ligands |
| Comments: Orphan |
Download all structure-activity data for this target as a CSV file 
| Agonists |
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Antagonists |
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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| DNA Binding |
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| DNA Binding Comments | |||||||
| ERRα and β bind SFREs (SF1 Response Elements: TNA AGGTCA) and EREs (Estrogen Responsive Elements) in vitro and that ERRα interact with these elements as a dimer. Interestingly, ERRs recognized only a subset of EREs. For example ERRα recognize EREs presenting the sequence AG AGGTCA NNN TGACCT CT whereas ERRβ recognize (C/A)G AGGTCA NNN TGACCT G(C/A). In vivo data and large scale analysis of promoter binding indicate that ERRβ interact with SFREs (V. Giguère, personal communication). | |||||||
| Co-binding Partners |
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| Name | Interaction | Effect | Reference |
| Hsp90 | Physical, Functional | DNA Binding: Efficient homodimerization and DNA-binding of ERRβ is dependent on interaction with the heat shock protein 90 (Hsp90) | 5 |
| Main Co-regulators |
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| Name | Activity | Specific | Ligand dependent | AF-2 dependent | Comments | References |
| PNRC1 | Co-activator | No | Yes | Yes | 6 | |
| NCOA3 | Co-activator | No | No | Yes | 8 | |
| NCOA2 | Co-activator | No | No | Yes | 8 | |
| NCOA1 | Co-activator | No | No | Yes | 8 | |
| Tissue Distribution
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| Physiological Consequences of Altering Gene Expression
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| Phenotypes, Alleles and Disease Models
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Mouse data from MGI | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Clinically-Relevant Mutations and Pathophysiology
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| Biologically Significant Variants
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| Biologically Significant Variant Comments | ||||||||
| Short-form hERRβ is widely expressed whereas other isoforms are restricted to testis and kidney. |
1. Chen F, Zhang Q, McDonald T, Davidoff MJ, Bailey W, Bai C, Liu Q, Caskey CT. (1999) Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR. Gene, 228 (1-2): 101-9. [PMID:10072763]
2. Giguère V, Yang N, Segui P, Evans RM. (1988) Identification of a new class of steroid hormone receptors. Nature, 331 (6151): 91-4. [PMID:3267207]
3. Luo J, Sladek R, Bader JA, Matthyssen A, Rossant J, Giguère V. (1997) Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-beta. Nature, 388 (6644): 778-82. [PMID:9285590]
4. Luo J, Sladek R, Carrier J, Bader JA, Richard D, Giguère V. (2003) Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha. Mol Cell Biol, 23 (22): 7947-56. [PMID:14585956]
5. Pettersson K, Svensson K, Mattsson R, Carlsson B, Ohlsson R, Berkenstam A. (1996) Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis. Mech Dev, 54 (2): 211-23. [PMID:8652414]
6. Suetsugi M, Su L, Karlsberg K, Yuan YC, Chen S. (2003) Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors. Mol Cancer Res, 1 (13): 981-91. [PMID:14638870]
7. Tremblay GB, Kunath T, Bergeron D, Lapointe L, Champigny C, Bader JA, Rossant J, Giguère V. (2001) Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERR beta. Genes Dev, 15 (7): 833-8. [PMID:11297507]
8. Xie W, Hong H, Yang NN, Lin RJ, Simon CM, Stallcup MR, Evans RM. (1999) Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2. Mol Endocrinol, 13 (12): 2151-62. [PMID:10598588]
9. Yu DD, Forman BM. (2005) Identification of an agonist ligand for estrogen-related receptors ERRbeta/gamma. Bioorg Med Chem Lett, 15 (5): 1311-3. [PMID:15713377]
10. Zhou W, Liu Z, Wu J, Liu JH, Hyder SM, Antoniou E, Lubahn DB. (2006) Identification and characterization of two novel splicing isoforms of human estrogen-related receptor beta. J Clin Endocrinol Metab, 91 (2): 569-79. [PMID:16332939]
3B. Estrogen-related receptors: Estrogen-related receptor-β. Last modified on 23/10/2014. Accessed on 22/01/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=623.
