Gene and Protein Information
class A G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	515	15q14-q15.1	GPR176	G protein-coupled receptor 176	1
Mouse	7	515	2 E5	Gpr176	G protein-coupled receptor 176
Rat	7	513	3q35	Gpr176	G protein-coupled receptor 176

Previous and Unofficial Names

HB954 | G-protein coupled receptor AGR9 | RBU-15

Database Links
Specialist databases
GPCRdb	gp176_human (Hs), gp176_mouse (Mm), gp176_rat (Rn)
Other databases
Alphafold	Q14439 (Hs), Q80WT4 (Mm), Q64017 (Rn)
ChEMBL Target	CHEMBL4523869 (Hs)
Ensembl Gene	ENSG00000166073 (Hs), ENSMUSG00000040133 (Mm), ENSRNOG00000005971 (Rn)
Entrez Gene	11245 (Hs), 381413 (Mm), 117257 (Rn)
Human Protein Atlas	ENSG00000166073 (Hs)
KEGG Gene	hsa:11245 (Hs), mmu:381413 (Mm), rno:117257 (Rn)
OMIM	612183
Pharos	Q14439 (Hs)
RefSeq Nucleotide	NM_007223 (Hs), NM_201367 (Mm), NM_001270986 (Rn)
RefSeq Protein	NP_009154 (Hs), NP_958755 (Mm), NP_001257915 (Rn)
UniProtKB	Q14439 (Hs), Q80WT4 (Mm), Q64017 (Rn)
Wikipedia	GPR176 (Hs)

Tissue Distribution
Brain, spleen, lung, kidney, intestine, cultured rat aortic smooth muscle Species:  Rat Technique:  Northern blot References:  1-2
Tissue Distribution Comments
Highest levels of expression are seen in human ovary, embryonic and nerve tissues (based on Unigene EST profile).

Expression Datasets
Show »« Hide Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website] There should be a chart of expression data here, you may need to enable JavaScript!

Biologically Significant Variants
Type:  Single nucleotide polymorphism Species:  Human Amino acid change:  K77R Global MAF (%):  1 Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 14|6|17|3 Minor allele count:  C=0.099/216 SNP accession:  rs66490630 Validation:  1000 Genomes, Frequency
Biologically Significant Variant Comments
The RefSeq gene (Gene ID:11245) has 3 coding exons, first contains most of TM 1, second contains most of TMs 2 and 3. There are a number of cDNAs which insert an extra 58 base exon between exons 1 and 2 and then use a compensating shorter (by 61 bases at acceptor end) version of exon 2. These alternate splice variants seem to be associated with one allele of the SNP rs66490630 which is the last base of the extra exon.