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GPR22

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Target not currently curated in GtoImmuPdb

Target id: 93

Nomenclature: GPR22

Family: Class A Orphans

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 433 7q22.3 GPR22 G protein-coupled receptor 22 5
Mouse 7 432 12 A3 Gpr22 G protein-coupled receptor 22
Rat 7 432 6q16 Gpr22 G protein-coupled receptor 22
Database Links Click here for help
Specialist databases
GPCRdb gpr22_human (Hs), gpr22_mouse (Mm), d4a3u0_rat (Rn)
Other databases
Alphafold Q99680 (Hs), Q8BZL4 (Mm), D4A3U0 (Rn)
ChEMBL Target CHEMBL4523914 (Hs)
Ensembl Gene ENSG00000172209 (Hs), ENSMUSG00000044067 (Mm), ENSRNOG00000008423 (Rn)
Entrez Gene 2845 (Hs), 73010 (Mm), 298944 (Rn)
Human Protein Atlas ENSG00000172209 (Hs)
KEGG Gene hsa:2845 (Hs), mmu:73010 (Mm), rno:298944 (Rn)
OMIM 601910 (Hs)
Pharos Q99680 (Hs)
RefSeq Nucleotide NM_005295 (Hs), NM_175191 (Mm), NM_001106722 (Rn)
RefSeq Protein NP_005286 (Hs), NP_780400 (Mm), NP_001100192 (Rn)
UniProtKB Q99680 (Hs), Q8BZL4 (Mm), D4A3U0 (Rn)
Wikipedia GPR22 (Hs)
Primary Transduction Mechanisms Click here for help
Transducer Effector/Response
Gi/Go family Adenylyl cyclase inhibition
References:  1
Tissue Distribution Click here for help
Frontal cortex, caudate, putamen, thalamus
Species:  Human
Technique:  Northern blot
References:  5
Brain (cerebellum, cerebral cortex, amygdala), heart
Species:  Human
Technique:  Microarray analysis, Affymetrix GeneChip platform
References:  4
Brain (accumbens, amygdala, cerebellum, cortex, hippocampus), heart (myocardial enrichment)
Species:  Human
Technique:  Northern blot, RT-PCR
References:  1
Brain, heart
Species:  Mouse
Technique:  Northern blot, In situ hybridisation
References:  1
Articular cartilage of knee
Species:  Mouse
Technique:  Immunohistochemistry
References:  3
Brain, heart (cardiomyocytes, coronary arteries)
Species:  Rat
Technique:  Northern blot, Immunohistochemistry
References:  1
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Physiological Functions Comments
Myocardial mRNA expression reduced following aortic banding suggesting a protective role in the hemodynamic stress response associated with increased afterload [1].
Physiological Consequences of Altering Gene Expression Click here for help
Increased succeptibility to functional decompensation following aortic banding
Species:  Mouse
Tissue:  Heart
Technique:  Gene knockout
References:  1
Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Gpr22tm1.1Jwad Gpr22tm1.1Jwad/Gpr22tm1.1Jwad
involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL		 MGI:1920260  MP:0004485 increased response of heart to induced stress PMID: 18539757 
Gpr22tm1Jwad Gpr22tm1Jwad/Gpr22tm1Jwad
involves: 129/Sv * C57BL/6 * SJL		 MGI:1920260  MP:0002169 no abnormal phenotype detected PMID: 18539757 
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Osteoarthritis
Disease Ontology: DOID:8398
Role:  Genome wide association studies (GWAS) has linked a locus on chromosome 7q22, including GPR22, with osteoarthritis. GPR22-positive chodrocyte-like cells have been found in osteophytes in instability-induced osteoarthritis.
References:  2-3,6

References

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1. Adams JW, Wang J, Davis JR, Liaw C, Gaidarov I, Gatlin J, Dalton ND, Gu Y, Ross J, Behan D, Chien K, Connolly D. (2008) Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor. Am J Physiol Heart Circ Physiol, 295 (2): H509-21. [PMID:18539757]

2. Evangelou E, Valdes AM, Kerkhof HJ, Styrkarsdottir U, Zhu Y, Meulenbelt I, Lories RJ, Karassa FB, Tylzanowski P, Bos SD et al.. (2011) Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Ann Rheum Dis, 70 (2): 349-55. [PMID:21068099]

3. Kerkhof HJ, Lories RJ, Meulenbelt I, Jonsdottir I, Valdes AM, Arp P, Ingvarsson T, Jhamai M, Jonsson H, Stolk L, Thorleifsson G, Zhai G, Zhang F, Zhu Y, van der Breggen R, Carr A, Doherty M, Doherty S, Felson DT, Gonzalez A, Halldorsson BV, Hart DJ, Hauksson VB, Hofman A, Ioannidis JP, Kloppenburg M, Lane NE, Loughlin J, Luyten FP, Nevitt MC, Parimi N, Pols HA, Rivadeneira F, Slagboom EP, Styrkársdóttir U, Tsezou A, van de Putte T, Zmuda J, Spector TD, Stefansson K, Uitterlinden AG, van Meurs JB. (2010) A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Arthritis Rheum, 62 (2): 499-510. [PMID:20112360]

4. Lee J, Hever A, Willhite D, Zlotnik A, Hevezi P. (2005) Effects of RNA degradation on gene expression analysis of human postmortem tissues. FASEB J, 19 (10): 1356-8. [PMID:15955843]

5. O'Dowd BF, Nguyen T, Jung BP, Marchese A, Cheng R, Heng HH, Kolakowski LF, Lynch KR, George SR. (1997) Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes. Gene, 187 (1): 75-81. [PMID:9073069]

6. Valdes AM, Spector TD. (2010) The genetic epidemiology of osteoarthritis. Curr Opin Rheumatol, 22 (2): 139-43. [PMID:20090528]

Contributors

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