Top ▲
Gene and Protein Information | ||||||
class A G protein-coupled receptor | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 7 | 337 | 10q26.13 | GPR26 | G protein-coupled receptor 26 | 4-5 |
Mouse | 7 | 337 | 7 F3 | Gpr26 | G protein-coupled receptor 26 | |
Rat | 7 | 337 | 1q41 | Gpr26 | G protein-coupled receptor 26 | 4 |
Database Links | |
Specialist databases | |
GPCRdb | gpr26_human (Hs), gpr26_mouse (Mm), gpr26_rat (Rn) |
Other databases | |
Alphafold | Q8NDV2 (Hs), Q8BZA7 (Mm), Q9QXI3 (Rn) |
ChEMBL Target | CHEMBL4523895 (Hs) |
Ensembl Gene | ENSG00000154478 (Hs), ENSMUSG00000040125 (Mm), ENSRNOG00000047057 (Rn) |
Entrez Gene | 2849 (Hs), 233919 (Mm), 192153 (Rn) |
Human Protein Atlas | ENSG00000154478 (Hs) |
KEGG Gene | hsa:2849 (Hs), mmu:233919 (Mm), rno:192153 (Rn) |
OMIM | 604847 (Hs) |
Pharos | Q8NDV2 (Hs) |
RefSeq Nucleotide | NM_153442 (Hs), NM_173410 (Mm), NM_138841 (Rn) |
RefSeq Protein | NP_703143 (Hs), NP_775586 (Mm), NP_620196 (Rn) |
UniProtKB | Q8NDV2 (Hs), Q8BZA7 (Mm), Q9QXI3 (Rn) |
Wikipedia | GPR26 (Hs) |
Primary Transduction Mechanisms | |
Transducer | Effector/Response |
Gs family | Adenylyl cyclase stimulation |
References: 3 |
Tissue Distribution | ||||||||
|
||||||||
|
||||||||
|
||||||||
|
||||||||
|
||||||||
Tissue Distribution Comments | ||||||||
RT-PCR carried by Zhang et al did not detect GPR26 in testis [6]. |
Expression Datasets | |
|
Physiological Consequences of Altering Gene Expression | ||||||||||
|
Gene Expression and Pathophysiology Comments | |
Epigenetic silencing of GPR26 is associated with human glioblastoma [1-2]. |
1. Boulay JL, Ionescu MC, Sivasankaran B, Labuhn M, Dolder-Schlienger B, Taylor E, Morin P, Hemmings BA, Lino MM, Jones G, Maier D, Merlo A. (2009) The 10q25.3-26.1 G protein-coupled receptor gene GPR26 is epigenetically silenced in human gliomas. Int J Oncol, 35 (5): 1123-31. [PMID:19787267]
2. Carter AN, Cole CL, Playle AG, Ramsay EJ, Shervington AA. (2008) GPR26: a marker for primary glioblastoma?. Mol Cell Probes, 22 (2): 133-7. [PMID:18037267]
3. Jones PG, Nawoschik SP, Sreekumar K, Uveges AJ, Tseng E, Zhang L, Johnson J, He L, Paulsen JE, Bates B, Pausch MH. (2007) Tissue distribution and functional analyses of the constitutively active orphan G protein coupled receptors, GPR26 and GPR78. Biochim Biophys Acta, 1770 (6): 890-901. [PMID:17363172]
4. Lee DK, Lynch KR, Nguyen T, Im DS, Cheng R, Saldivia VR, Liu Y, Liu IS, Heng HH, Seeman P, George SR, O'Dowd BF, Marchese A. (2000) Cloning and characterization of additional members of the G protein-coupled receptor family. Biochim Biophys Acta, 1490 (3): 311-23. [PMID:10684976]
5. Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF. (2001) Discovery and mapping of ten novel G protein-coupled receptor genes. Gene, 275 (1): 83-91. [PMID:11574155]
6. Zhang LL, Wang JJ, Liu Y, Lu XB, Kuang Y, Wan YH, Chen Y, Yan HM, Fei J, Wang ZG. (2011) GPR26-deficient mice display increased anxiety- and depression-like behaviors accompanied by reduced phosphorylated cyclic AMP responsive element-binding protein level in central amygdala. Neuroscience, 196: 203-14. [PMID:21924326]