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Consequences of altering gene expression: accumulation of the amyloid-beta peptide in vitro and in an Alzheimer's disease mouse model
Mutations/pathophysiology - disease: Alzheimer disease
Mutations/pathophysiology - disease: Alzheimer's disease aka Alzheimer disease
Mutations/pathophysiology - role: neurons and may be a potential therapeutic target for the treatment of Alzheimer's disease
Mutations/pathophysiology - disease: Alzheimer's disease aka Alzheimer disease
Mutations/pathophysiology - role: Alzheimer's disease anti-PD1 antibody treatment was used to induce immune checkpoint blockade. The biological
Receptor Immuno Comment: Alzheimer's disease (AD): In mouse models of AD anti-PD-1 antibody treatment was used
Mutations/pathophysiology - disease: Alzheimer disease 4
Mutations/pathophysiology - disease: Early-onset autosomal dominant Alzheimer disease aka Alzheimer disease 4
Mutations/pathophysiology - disease: Alzheimer's disease aka Alzheimer disease 4
Clinical use: Alzheimer's Association International Conference in Toronto (July 2016) and reported on the NewScientist website
Mechanism of action: Alzheimer's plaques and filaments respectively. Inhibition of the formation of tau filaments/tangles is one strategy
Clinical use: flortaucipir F18 as a radioactive diagnostic agent for PET scans of patients being evaluated for Alzheimer's disease.
Bioactivity comments: Alzheimer's disease patients . Flortaucipir (18F) signal co-localises with beta-amyloid, but does not bind
Clinical use: Abeta) as a diagnostic biomarker in the brains of patients with Alzheimer's disease (AD) .
Mechanism of action: Alzheimer's disease. The 18F radioactive tracer can then be detected by PET scanning and its accumulation
Clinical use: Alzheimer's disease in June 2015. These trials, NCT02423200 and NCT02423122, have now been completed
Immuno Ligand Comments: Alzheimer's disease, as predicted by preclinical assessment in a mouse model of the disease
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