INN: remdesivir Comments: Remdesivir (GS-5734) is a nucleotide analogue drug that was developed by Gilead Sciences for antiviral Clinical use: Remdesivir (GS-5734) must be administered by intravenous (i.v.) infusion. Remdesivir progressed to Phase 2 evaluation Mechanism of action: Remdesivir is a phosphoramidate adenosine nucleotide analogue that blocks viral RNA-dependent RNA polymerase (RdRp Bioactivity comments: Remdesivir (GS-5734) inhibits SARS-CoV and MERS-CoV replication in multiple in vitro systems
Comments: remdesivir. Like its parent, this prodrug results in inhibition of viral RNA-dependent RNA polymerase Bioactivity comments: EC50 of 125 nM . In the same assay system remdesivir's EC50 was 37 nM.
Comments: remdesivir. GS-441524 potently inhibits SARS-CoV-2 replication in in vitro and in vivoinfection Bioactivity comments: remdesivir (IC50 1.35 muM) . However the opposite is true in Calu-3 and Caco-2 cells
Comment: remdesivir. Although RdRp (nsp12) is strictly a component of the SARS-CoV-2 replicase polyprotein 3D structure - description: nsp7-nsp8 complex bound to the template-primer RNA and triphosphate form of Remdesivir(RTP)