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Ligand: remdesivir
INN: remdesivir
Comments: Remdesivir (GS-5734) is a nucleotide analogue drug that was developed by Gilead Sciences for antiviral
Clinical use: Remdesivir (GS-5734) must be administered by intravenous (i.v.) infusion. Remdesivir progressed to Phase 2 evaluation
Mechanism of action: Remdesivir is a phosphoramidate adenosine nucleotide analogue that blocks viral RNA-dependent RNA polymerase (RdRp
Bioactivity comments: Remdesivir (GS-5734) inhibits SARS-CoV and MERS-CoV replication in multiple in vitro systems
Ligand: GS-441524
Comments: remdesivir. GS-441524 potently inhibits SARS-CoV-2 replication in in vitro and in vivoinfection
Bioactivity comments: remdesivir (IC50 1.35 muM) . However the opposite is true in Calu-3 and Caco-2 cells
Ligand: molnupiravir
Bioactivity comments: remdesivir and EIDD-2801 is that while remdesivir needs to be administered intravenously within a medical
Ligand: PF-07304814
Bioactivity comments: clades from clinical isolates in A549+ACE2 cells, and was statistically more potent than remdesivir .
Target: CoV RNA-dependent RNA polymerase (Coronavirus (CoV) proteins)
Comment: remdesivir. Although RdRp (nsp12) is strictly a component of the SARS-CoV-2 replicase polyprotein
Target: CoV Replicase polyprotein 1ab (Coronavirus (CoV) proteins)
Comment: remdesivir, tenofovir and ribavirin . It has a zinc-binding domain in its N-terminus and its activity

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