Comments: gamma-secretase modulator (GSM) that blocks gamma-secretase cleavage of amyloid-beta protein precursor (AbetaPP Bioactivity comments: Mechanism of action thought to be gammasecretase modulation but no quantitiative data reported.
Comments: gamma-secretase inhibitor (GSI) for Alzheimer's Disease that selectively inhibits cleavage of APP over Bioactivity comments: gamma-secretase function, and displaces a tritiated analog of GSI-953 from enriched gamma-secretase
Comments: gamma-secretase inhibitor. PF-3084014 also acts as an inhibitor of the NOTCH signalling pathway Bioactivity comments: gamma-secretase activity with an IC50 of 1.2nM , measured as a reduction of Abeta
Comments: gamma-secretase modulator (GSM). These are small molecules (<600 Da) causing a product shift from Bioactivity comments: Note as a GSM the potency of gammasecretase inhibition is low
Comments: gamma-secretase, was originally developed for Alzheimer's disease but based on its ability to inhibit Bioactivity comments: RO4929097 strongly inhibits gamma-secretase enzyme activity.
Comments: gamma-secretase inhibitor that was developed by Eli Lilly as a potential treatment for Alzheimer Bioactivity comments: Shows potent Inhibition of gammasecretase-mediated amyloid beta (1 to 40) production in vitro