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Type XIII RTKs: Ephrin receptor family C

Formerly known as: Ephrin receptor family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Ephrin receptors are a family of 15 RTKs (the largest family of RTKs) with two identified subfamilies (EphA and EphB), which have a role in the regulation of neuronal development, cell migration, patterning and angiogenesis. Their ligands are membrane-associated proteins, thought to be glycosylphosphatidylinositol-linked for EphA (ephrin-A1 (EFNA1, P20827) , ephrin-A2 (EFNA2, O43921), ephrin-A3 (EFNA3, P52797), ephrin-A4 (EFNA4, P52798) and ephrin-A5 (EFNA5, P52803)) and 1TM proteins for Ephrin B (ENSFM00250000002014: ephrin-B1 (EFNB1, P98172), ephrin-B2 (EFNB2, P52799) and ephrin-B3 (EFNB3, Q15768)), although the relationship between ligands and receptors has been incompletely defined.

Receptors

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EphA1 (EPH receptor A1) C Show summary » More detailed page go icon to follow link

EphA2 (EPH receptor A2) C Show summary » More detailed page go icon to follow link

EphA3 (EPH receptor A3) C Show summary » More detailed page go icon to follow link

EphA4 (EPH receptor A4) C Show summary » More detailed page go icon to follow link

EphA5 (EPH receptor A5) C Show summary » More detailed page go icon to follow link

EphA6 (EPH receptor A6) C Show summary » More detailed page go icon to follow link

EphA7 (EPH receptor A7) C Show summary » More detailed page go icon to follow link

EphA8 (EPH receptor A8) C Show summary » More detailed page go icon to follow link

EphA10 (EPH receptor A10) C Show summary » More detailed page go icon to follow link

EphB1 (EPH receptor B1) C Show summary » More detailed page go icon to follow link

EphB2 (EPH receptor B2) C Show summary » More detailed page go icon to follow link

EphB3 (EPH receptor B3) C Show summary » More detailed page go icon to follow link

EphB4 (EPH receptor B4) C Show summary » More detailed page go icon to follow link

EphB6 (EPH receptor B6) C Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

Type XIII RTKs: Ephrin receptor family. Accessed on 15/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=327.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Catalytic receptors. Br J Pharmacol. 176 Suppl 1: S247-S296.