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Bacterial protein targets C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Antimicrobial resistance is recognized by the World Health Organization (WHO) as a major global health threat, and it is estimated that drug-resistant infections contribute to almost 5 million deaths a year [3]. The rapid spread of bacterial strains resistant to available antibacterial medicines is of particular concern, including the 'ESKAPE' pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) that are responsible for many nosocomial infections [7-8].
Antibacterial compounds act on essential bacterial molecular pathways, resulting in inhibition of growth or death of the microorganisms. These mechanisms of action include: altered DNA replication and structure, cell membrane integrity, and inhibition of cell wall peptidoglycan synthesis, nucleic acid precursor synthesis and protein synthesis.

Targets

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Complexes

DNA gyrase C Show summary » More detailed page go icon to follow link

DNA topoisomerase 4 Show summary » More detailed page go icon to follow link

Targets and Subunits

DNA gyrase subunit A C Show summary » More detailed page go icon to follow link

DNA gyrase subunit B C Show summary » More detailed page go icon to follow link

DNA topoisomerase 4 subunit A Show summary » More detailed page go icon to follow link

DNA topoisomerase 4 subunit B Show summary » More detailed page go icon to follow link

polyketide synthase Pks13 Show summary » More detailed page go icon to follow link

Further reading

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References

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How to cite this family page

Database page citation:

Bacterial protein targets. Accessed on 23/02/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1074.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.