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H+/K+-ATPases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The H+/K+ ATPase is a heterodimeric protein, made up of α and β subunits. The α subunit has 10 TM domains and exhibits catalytic and pore functions, while the β subunit has a single TM domain, which appears to be required for intracellular trafficking and stabilising the α subunit. The ATP4A and ATP4B subunits are expressed together, while the ATP12A subunit is suggested to be expressed with the β1 (ATP1B1) subunit of the Na+/K+-ATPase [1].


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ATP4A Show summary » More detailed page go icon to follow link

ATP12A Show summary »

Target Id 850
Nomenclature ATP12A
Previous and unofficial names ATP1AL1 | ATPase | ATPase H+K+-transporting, alpha 2 | ATPase, H+/K+ transporting, nongastric, alpha polypeptide | cHKA | HKalpha2 | H-K-ATPase alpha 2 | hydrogen/potassium-exchanging ATPase 12A | non-gastric H+/K+-ATPase α subunit | potassium-transporting ATPase alpha chain 2
Genes ATP12A (Hs), Atp12a (Mm), Atp12a (Rn)
Ensembl ID ENSG00000075673 (Hs), ENSMUSG00000022229 (Mm), ENSRNOG00000020685 (Rn)
UniProtKB AC P54707 (Hs), Q9Z1W8 (Mm), P54708 (Rn)
EC number

ATP4B Show summary »


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Further reading

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How to cite this family page

Database page citation:

H+/K+-ATPases. Accessed on 22/02/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.