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H+/K+-ATPases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The H+/K+ ATPase is a heterodimeric protein, made up of α and β subunits. The α subunit has 10 TM domains and exhibits catalytic and pore functions, while the β subunit has a single TM domain, which appears to be required for intracellular trafficking and stabilising the α subunit. The ATP4A and ATP4B subunits are expressed together, while the ATP12A subunit is suggested to be expressed with the β1 (ATP1B1) subunit of the Na+/K+-ATPase [1].


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ATP4A Show summary » More detailed page go icon to follow link

ATP12A Show summary »

ATP4B Show summary »

Target Id 851
Nomenclature ATP4B
Previous and unofficial names ATP6B | ATPase | ATPase, H+/K+ exchanging, beta polypeptide | ATPase H+/K+ transporting beta subunit | gastric H+/K+-ATPase β subunit | H+/K+-ATPase beta | proton pump beta chain
Genes ATP4B (Hs), Atp4b (Mm), Atp4b (Rn)
Ensembl ID ENSG00000186009 (Hs), ENSMUSG00000031449 (Mm), ENSRNOG00000018543 (Rn)
UniProtKB AC P51164 (Hs), P50992 (Mm), P18598 (Rn)
EC number


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Further reading

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How to cite this family page

Database page citation:

H+/K+-ATPases. Accessed on 27/01/2023. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.