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Neutral amino acid transporter subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Certain members of neutral amino acid transport family are expressed upon the apical surface of epithelial cells and are important for the absorption of amino acids from the duodenum, jejunum and ileum and their reabsorption within the proximal tubule of the nephron (i.e. B0AT1 (SLC6A19), SLC6A18, SLC6A20). Others may function as transporters for neurotransmitters or their precursors (i.e. B0AT2, SLC6A17) [5]. B0AT1 has been proposed as a drug target to treat phenylketonuria [1].

Transporters

939
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B0AT1 / SLC6A19 C Show summary »


Target Id 939
Nomenclature B0AT1
Systematic nomenclature SLC6A19
Previous and unofficial names B0 neutral amino acid transporter | sodium-dependent neutral amino acid transporter B(0)AT1 | solute carrier family 6 (neurotransmitter transporter), member 19 | solute carrier family 6 member 19 | solute carrier family 6 (neutral amino acid transporter), member 19 | solute carrier family 6 (neurotransmitter transporter)
Genes SLC6A19 (Hs), Slc6a19 (Mm), Slc6a19 (Rn)
Ensembl ID ENSG00000174358 (Hs), ENSMUSG00000021565 (Mm), ENSRNOG00000026501 (Rn)
UniProtKB AC Q695T7 (Hs), Q9D687 (Mm), Q2A865 (Rn)
Bioparadigms SLC Tables SLC6A19 (Hs)
Endogenous substrates L-leucine, L-methionine, L-isoleucine, L-valine > L-asparagine, L-phenylalanine, L-alanine, L-serine > L-threonine, glycine, L-proline  [4]
Inhibitors
cinromide pIC50 6.4 [9]
inhibitor E18 pIC50 5.5 [13]
inhibitor CB3 pIC50 5.3 [13]
inhibitor E4 pIC50 5.1 [13]
nimesulide pIC50 4.6 [10] - Rat
benzatropine pIC50 4.4 [7]
Stoichiometry 1 Na+: 1 amino acid [6]
Comment Mutations in B0AT1 are associated with Hartnup disorder

B0AT2 / SLC6A15 C Show summary »

B0AT3 / SLC6A18 C Show summary »

NTT5 / SLC6A16 C Show summary »

NTT4 / SLC6A17 C Show summary »

SIT1 / SLC6A20 C Show summary »

References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.